Evidence map›Paper›PMID 28197542›Full record

ArticleeNeuro

The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded

Rahul Gupta, Matthews Lan, Jelena Mojsilovic-Petrovic, Won Hoon Choi, Nathaniel Safren, Sami Barmada, Min Jae Lee, Robert Kalb

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Rahul GuptaDepartment of Chemical and Biomolecular Engineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, 19104; Department of Biology, College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104.ORCID 0000-0001-8263-2455
Matthews LanDepartment of Biochemistry, College of Arts and Sciences, University of Pennsylvania , Philadelphia, PA, 19104.
Jelena Mojsilovic-PetrovicDivision of Neurology, Department of Pediatrics, Research Institute, Children's Hospital of Philadelphia , Philadelphia, PA, 19104.
Won Hoon ChoiDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine , Seoul 03080, Republic of Korea.
Nathaniel SafrenDepartment of Neurology, University of Michigan , Ann Arbor, MI, 48109.
Sami BarmadaDepartment of Neurology, University of Michigan , Ann Arbor, MI, 48109.
Min Jae LeeDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine , Seoul 03080, Republic of Korea.ORCID 0000-0002-3252-6467
Robert KalbDivision of Neurology, Department of Pediatrics, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA, 19104; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
Children's Hospital of Philadelphia · USSeoul National University · KRUniversity of Michigan · USUniversity of the Sciences · US

Funding

Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1M
RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degenerationR01NS097542 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2016 to 2025
$3.8M
NIA NIH HHS P30 AG053760NINDS NIH HHS R01 NS097542
6 · The paper itself

Abstract

An intronic hexanucleotide repeat expansion (HRE) mutation in the

Indexed as

AnimalsAstrocytesCell DeathCells, CulturedCerebral CortexCoculture TechniquesDNA Repeat ExpansionGuanine Nucleotide Exchange FactorsHEK293 CellsHumansNeuronsPeptidesProteasome Endopeptidase ComplexProteasome InhibitorsRats, Sprague-DawleySpinal CordGR20 peptideGuanine Nucleotide Exchange FactorsPeptidesPR20 peptideProteasome Endopeptidase ComplexProteasome InhibitorsALSfrontotemporal dementialysosome-autophagymotor neuronproteasome

Identifiers

PMID28197542
PMCPMC5282547
OpenAlexW2580212715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.