ArticleThe Journal of physiology2017
Prolactin regulation of oxytocin neurone activity in pregnancy and lactation.
Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- Molecular Regulatory Mechanisms of Mammary Gland Development: A Review.Animals : an open access journal from MDPI · 2025Review
- Maternal aggression driven by the transient mobilisation of a dormant hormone-sensitive circuit.Nature communications · 2025Article
- Neuroendocrine Regulation and Neural Circuitry of Parenthood: Integrating Neuropeptides, Brain Receptors, and Maternal Behavior.International journal of molecular sciences · 2025Review
- Lifetime Variations in Prolactin Expression in the Hippocampus and Dentate Gyrus of the Rat.International journal of molecular sciences · 2025Article
- Abscisic acid regulates maternal behavior in rats via PPARγ receptors and hypothalamic oxytocin signaling.Iranian journal of veterinary research · 2025Article
- Article
- Oxytocin Receptor-Expressing Neurons in the Medial Preoptic Area Are Essential for Lactation, whereas Those in the Lateral Septum Are Not Critical for Maternal Behavior.Neuroendocrinology · 2024Article
- Retrospective analysis on the efficacy of epidural labor analgesia on early breast feeding after vaginal delivery.BMC anesthesiology · 2023Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Exploring a Possible Interplay between Schizophrenia, Oxytocin, and Estrogens: A Narrative Review.Brain sciences · 2023Review
- Hormone supply to the pituitary gland: A comprehensive investigation of female‑related tumors (Review).International journal of molecular medicine · 2022Review
- α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation.Physiological reports · 2022Article
- A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females.International journal of molecular sciences · 2022Review
- Neonatal oxytocin gives the tempo of social and feeding behaviors.Frontiers in molecular neuroscience · 2022Review
- Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats.Iranian journal of basic medical sciences · 2021Article
- Love and longevity: A Social Dependency Hypothesis.Comprehensive psychoneuroendocrinology · 2021Review
- Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms.International journal of molecular sciences · 2021Review
- Plasticity in Intrinsic Excitability of Hypothalamic Magnocellular Neurosecretory Neurons in Late-Pregnant and Lactating Rats.International journal of molecular sciences · 2021Article
- Prolactin enhances hippocampal synaptic plasticity in female mice of reproductive age.Hippocampus · 2021Article
- Expression Profile Analysis to Identify Circular RNA Expression Signatures in the Prolificacy Trait of Yunshang Black Goat Pituitary in the Estrus Cycle.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsDuring lactation, prolactin promotes milk synthesis and oxytocin stimulates milk ejection. In virgin rats, prolactin inhibits the activity of oxytocin-secreting neurones. We found that prolactin inhibition of oxytocin neurone activity is lost in lactation, and that some oxytocin neurones were excited by prolactin in lactating rats. The change in prolactin regulation of oxytocin neurone activity was not associated with a change in activation of intracellular signalling pathways known to couple to prolactin receptors. The change in prolactin regulation of oxytocin neurone activity in lactation might allow coordinated activation of both populations of neurones when required for successful lactation. ABSTRACT: Secretion of prolactin for milk synthesis and oxytocin for milk secretion is required for successful lactation. In virgin rats, prolactin inhibits oxytocin neurones but this effect would be counterproductive during lactation when secretion of both hormones is required for synthesis and delivery of milk to the newborn. Hence, we determined the effects of intracerebroventricular (i.c.v.) prolactin on oxytocin neurones in urethane-anaesthetised virgin, pregnant and lactating rats. Prolactin (2 μg) consistently inhibited oxytocin neurones in virgin and pregnant rats (by 1.9 ± 0.4 and 1.8 ± 0.5 spikes s
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.