Evidence map›Paper›PMID 28212289›Full record

ArticleNutrients2017

The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus.

Jasmine F Plows, Florence Budin, Rebecka A M Andersson, Valerie J Mills, Katherine Mace, Sandra T Davidge, Mark H Vickers, Philip N Baker, Irma Silva-Zolezzi, Joanna L Stanley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  12. The influence of D-Biomedical reports · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Jasmine F PlowsLiggins Institute, University of Auckland, Auckland 1021, New Zealand. jasmine.plows@auckland.ac.nz.
Florence BudinNestle Research Center, Lausanne 1000, Switzerland. florence.budin@rdls.nestle.com.
Rebecka A M AnderssonLiggins Institute, University of Auckland, Auckland 1021, New Zealand. reban468@student.liu.se.
Valerie J MillsLiggins Institute, University of Auckland, Auckland 1021, New Zealand. valeriejeanmills@gmail.com.
Katherine MaceNestle Research Center, Lausanne 1000, Switzerland. catherine.mace@rdls.nestle.com.
Sandra T DavidgeUniversity of Alberta, Edmonton, AB T6G 2R3, Canada. sandra.davidge@ualberta.ca.
Mark H VickersLiggins Institute, University of Auckland, Auckland 1021, New Zealand. m.vickers@auckland.ac.nz.
Philip N BakerLiggins Institute, University of Auckland, Auckland 1021, New Zealand. philip.baker@leicester.ac.uk.
Irma Silva-ZolezziNestle Research Center, Lausanne 1000, Switzerland. irma.silvazolezzi@rdls.nestle.com.
Joanna L StanleyLiggins Institute, University of Auckland, Auckland 1021, New Zealand. j.stanley@auckland.ac.nz.
University of Auckland · NZNestlé (Switzerland) · CHUniversity of Alberta · CAUniversity of Leicester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams). In addition, the individual effects of vitamin B2 were examined. Suboptimal B2 increased body weight and fat deposition, decreased GLUT4 adipose tissue expression, and increased expression of inflammatory markers. MI supplementation reduced weight and fat deposition, and reduced expression of inflammatory markers in adipose tissue of mice on suboptimal B2. MI also significantly reduced the hyperleptinemia observed in db/+ mice, when combined with supplemented B2. MI was generally associated with adipose tissue markers of improved insulin sensitivity and glucose uptake, while the combination of vitamins B2, B6, B12, and D was associated with a reduction in adipose inflammatory marker expression. These results suggest that supplementation with MI and vitamin B2 could be beneficial for the treatment/prevention of GDM.

Indexed as

Dietary SupplementsAdipose TissueAnimalsDiabetes, GestationalDiabetes Mellitus, ExperimentalDisease Models, AnimalFemaleInflammation MediatorsInositolMicePregnancyRiboflavinVitamin DVitaminsInflammation MediatorsInositolRiboflavinVitamin DVitaminsB12B2B6Ddb/+db/dbgestational diabetesLepRmicemyo-inositolRiboflavin

Identifiers

PMID28212289
PMCPMC5331572
OpenAlexW2588012853

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.