Evidence map›Paper›PMID 28212798›Full record

ReviewAdvances in pharmacology (San Diego, Calif.)2017

Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.

H C Ringvold, R A Khalil

Open access · greenAbstract readReview
In one paragraph

Review in Advances in pharmacology (San Diego, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 117 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The role of ferroptosis in vascular endothelial cells and its role in the pathogenesis of cervical spondylosis of vertebral artery type: a comprehensive review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  10. The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  11. Identification of Myeloid Protein Kinase C Epsilon as a Novel Atheroprotective Gene.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  12. Short-Term Intake ofAntioxidants (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Review
  15. International journal of molecular sciences · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Life (Basel, Switzerland) · 2024
    Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

H C RingvoldBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
R A KhalilBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: raouf_khalil@hms.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Vascular Mechanisms in Pregnancy-Induced HypertensionR01HL065998 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KHALIL, RAOUF A · 2002 to 2016
$4.3M
Role of Endothelin B Receptor in Vascular Protection in FemalesR21HL098724 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHALIL, RAOUF A · 2010 to 2011
$481k
Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous InsufficiencyR21HL111775 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHALIL, RAOUF A · 2013 to 2014
$475k
NHLBI NIH HHS R01 HL065998NHLBI NIH HHS R21 HL098724NHLBI NIH HHS R21 HL111775
6 · The paper itself

Abstract

Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In addition to Ca

Indexed as

AnimalsCalciumHumansIndolesMaleimidesMuscle ContractionMuscle, Smooth, VascularMyosin Light ChainsPhosphorylationProtein Kinase CVascular DiseasesVasoconstrictionCalciumIndolesMaleimidesMyosin Light ChainsProtein Kinase CruboxistaurinBlood vesselsCalciumContractionHypertensionProtein kinasesSignaling

Identifiers

PMID28212798
PMCPMC5319769
OpenAlexW2487819163

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.