ArticleProceedings of the National Academy of Sciences of the United States of America1987
Constitutive expression of a gene encoding a polypeptide homologous to biologically active human platelet protein in Rous sarcoma virus-transformed fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 126 citations in OpenAlex.
- Cellular processes of v-Src transformation revealed by gene profiling of primary cells--implications for human cancer.BMC cancer · 2010Article
- Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src.Virology · 2007Article
- Differential cytokine mRNA expression in heterophils isolated from Salmonella-resistant and -susceptible chickens.Immunology · 2004Article
- Differential cytokine responses following Marek's disease virus infection of chickens differing in resistance to Marek's disease.Journal of virology · 2003Article
- Marek's disease virus (MDV) encodes an interleukin-8 homolog (vIL-8): characterization of the vIL-8 protein and a vIL-8 deletion mutant MDV.Journal of virology · 2001Article
- Transformation of Rat-1 fibroblasts with the v-src oncogene induces inositol 1,4,5-trisphosphate 3-kinase expression.The Biochemical journal · 1996Article
- Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src.Molecular and cellular biology · 1996Article
- A Bcl-2-related gene is activated in avian cells transformed by the Rous sarcoma virus.The EMBO journal · 1995Article
- Alteration of in vivo DNA synthesis in the alpha globin locus of chick embryo fibroblasts due to in vivo activity of Rous sarcoma virus pp60src.Nucleic acids research · 1994Article
- Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.Molecular and cellular biology · 1993Article
- Transformation-associated cytokine 9E3/CEF4 is chemotactic for chicken peripheral blood mononuclear cells.Journal of virology · 1993Article
- Regulation of the junB gene by v-src.Molecular and cellular biology · 1992Article
- Transcriptional activation of the CEF-4/9E3 cytokine gene by pp60v-src.Molecular and cellular biology · 1992Article
- The 9E3 protein: immunolocalization in vivo and evidence for multiple forms in culture.Journal of cell science · 1992Article
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.The Journal of cell biology · 1991Article
- Wound-factor-induced and cell cycle phase-dependent expression of 9E3/CEF4, the avian gro gene.Cell regulation · 1991Article
- The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts.Molecular and cellular biology · 1991Article
- Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The v-src inducible gene 9E3/pCEF4 is regulated by both its promoter upstream sequence and its 3' untranslated region.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue.Molecular and cellular biology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A molecular clone corresponding to a 1.2-kilobase mRNA enriched in Rous sarcoma virus-transformed chicken embryo fibroblasts (CEF) was identified by differential screening of a cDNA library. The induction of the cloned sequence (denoted pCEF-4) in CEF infected by the temperature-sensitive mutant NY72-4 Rous sarcoma virus is rapid and independent of protein synthesis. DNA sequencing of the 1.2-kilobase insert of CEF-4 revealed an open reading frame that predicts an 11-kDa protein. The predicted pCEF-4 gene product is homologous to human connective tissue-activating peptide III (CTAP-III) and platelet factor 4 (PF-4). Serum stimulation of quiescent normal CEF results in a rapid but transient expression of pCEF-4 mRNA. Hence, pCEF-4 mRNA is expressed at the G0-G1 transition and during the first G1 phase of normal CEF reentering the cell cycle. The expression of pCEF-4 mRNA in Rous sarcoma virus-transformed CEF appears to be the result of transcriptional activation and stabilization of the transcript.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.