Evidence map›Paper›PMID 28223495›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.

János Hanics, Edit Szodorai, Giuseppe Tortoriello, Katarzyna Malenczyk, Erik Keimpema, Gert Lubec, Zsófia Hevesi, Mirjam I Lutz, Márk Kozsurek, Zita Puskár and 6 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Neuronal activity modulates the expression of secretagogin, a CaActa physiologica (Oxford, England) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. SCGN deficiency is a risk factor for autism spectrum disorder.Signal transduction and targeted therapy · 2023
    Article
  10. Review
  11. Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Article
  14. Structural and mechanistic insights into secretagogin-mediated exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. eLife · 2019
    Article
  19. Article
  20. 20 Years of Secretagogin: Exocytosis and Beyond.Frontiers in molecular neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

János HanicsMTA-SE NAP B Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, H-1051 Budapest, Hungary.
Edit SzodoraiDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria.
Giuseppe TortorielloDepartment of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Katarzyna MalenczykDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria.
Erik KeimpemaDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria.
Gert LubecDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, A-1090 Vienna, Austria.
Zsófia HevesiMTA-SE NAP B Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, H-1051 Budapest, Hungary.
Mirjam I LutzInstitute of Neurology, Medical University of Vienna, A-1090 Vienna, Austria.
Márk KozsurekDepartment of Anatomy, Histology, and Embryology, Semmelweis University, H-1085 Budapest, Hungary.
Zita PuskárDepartment of Anatomy, Histology, and Embryology, Semmelweis University, H-1085 Budapest, Hungary.
Zsuzsanna E TóthDepartment of Anatomy, Histology, and Embryology, Semmelweis University, H-1085 Budapest, Hungary.
Ludwig WagnerDepartment of Internal Medicine III, Medical University of Vienna, A-1090 Vienna, Austria.
Gábor G KovácsInstitute of Neurology, Medical University of Vienna, A-1090 Vienna, Austria.
Tomas G M HökfeltDepartment of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden, tomas.hokfelt@ki.se alpar.alan@med.semmelweis-univ.hu.
Tibor HarkanyDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria.
Alán AlpárMTA-SE NAP B Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, H-1051 Budapest, Hungary; tomas.hokfelt@ki.se alpar.alan@med.semmelweis-univ.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rostral migratory stream (RMS) is viewed as a glia-enriched conduit of forward-migrating neuroblasts in which chemorepulsive signals control the pace of forward migration. Here we demonstrate the existence of a scaffold of neurons that receive synaptic inputs within the rat, mouse, and human fetal RMS equivalents. These neurons express secretagogin, a Ca

Indexed as

AnimalsAnnexin A5CalciumCell MovementFetusGene Expression RegulationHumansMaleMatrix Metalloproteinase 2MiceMicrotomyNeurogliaNeuronsOlfactory BulbPrimary Cell CultureRatsAnnexin A5CalciumMatrix Metalloproteinase 2MMP2 protein, humanSecretagoginscalcium-binding proteincell motilityhuman fetusolfactory systemrestorative strategy

Identifiers

PMID28223495
PMCPMC5347634

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.