Evidence map›Paper›PMID 28228332›Full record

Trial reportNutrition, metabolism, and cardiovascular diseases : NMCD2017

Calorically restricted diets decrease PCSK9 in overweight adolescents.

A E Levenson, C E Milliren, S B Biddinger, C B Ebbeling, H A Feldman, D S Ludwig, S D de Ferranti

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01080339 (Change in Cardiometabolic Risk Factors During an Interactive Fitness Program), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01080339 terminatednot on this map

Change in Cardiometabolic Risk Factors During an Interactive Fitness Program: An Exploratory Sub-study

TypeobservationalSponsorBoston Children's HospitalRan2010 to 2011Enrolled3ConditionsInsulin Resistance
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

A E LevensonDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Amy.Levenson@unc.edu.
C E MillirenClinical Research Center, Boston Children's Hospital, Boston, MA, USA.
S B BiddingerDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
C B EbbelingNew Balance Foundation Obesity Prevention Center, Boston Children's Hospital, Boston, MA, USA.
H A FeldmanDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
D S LudwigDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, Boston, MA, USA.
S D de FerrantiDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Boston Children's Hospital · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
CAREER DEVELOPMENT IN DIABETES RESEARCH FOR PEDIATRIC ENDOCRINOLOGISTSK12DK094721 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LAFFEL, LORI M, WHITE, MORRIS F. · 2011 to 2021
$6.3M
Effects of Diet on Hormones, Metabolism and Body WeightK24DK082730 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LUDWIG, DAVID S · 2009 to 2018
$1.6M
Control of lipid metabolism in insulin resistant statesR01DK094162 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI BIDDINGER, SUDHA B · 2012 to 2015
$1.5M
Nutritional Treatment of Overweight Adolescents with Cardiovascular Risk FactorsK23HL085308 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DE FERRANTI, SARAH D · 2007 to 2011
$777k
NCRR NIH HHS UL1 RR025758NHLBI NIH HHS K23 HL085308NIDDK NIH HHS K12 DK094721NIDDK NIH HHS K24 DK082730NIDDK NIH HHS L40 DK065607NIDDK NIH HHS R01 DK094162
6 · The paper itself

Abstract

BACKGROUND AND

aimsNutritional therapy is the first line approach to treatment of hyperlipidemia in childhood. Proprotein convertase subtilisin kexin type 9 (PCSK9) is a key regulator of plasma cholesterol levels and a target of novel lipid-lowering pharmacotherapies. We examined the effects of an intensive nutritional intervention on PCSK9 levels in overweight adolescents with cardiovascular disease (CVD) risk factors. METHODS AND

resultsTwenty seven obese and overweight adolescents with CVD risk factors were assigned to either a low fat or low glycemic load diet. During an 8-week "Intensive Phase," assigned meals were delivered to the home, and all participants received weekly in-person home nutrition counseling and phone calls. The subjects then underwent a 4-month "Maintenance Phase" without food provision and with no in-person contact. Anthropometric measurements, laboratory data, and serum PCSK9 protein levels were measured at baseline, 8 weeks, and 6 months. PCSK9 decreased by 16.5% at 8 weeks (201.2 ± 56.3 vs 165.6 ± 58.4 ng/mL; p < 0.001); PCSK9 levels returned to baseline levels at 6 months, after the Maintenance Phase. Change in PCSK9 was associated with change in fasting insulin, HOMA-IR, and AUC insulin, independent of weight loss.

conclusionsPCSK9 decreased in youth participating in an intensive dietary intervention. Change in HOMA-IR was associated with change in PCSK9, independent of weight loss, suggesting an important relationship with insulin sensitivity. ClinicalTrials.gov Identifier: NCT01080339.

Indexed as

Diet, Fat-RestrictedEnergy IntakeGlycemic LoadAdolescentAge FactorsBiomarkersBlood GlucoseBostonChildCounselingDown-RegulationFemaleHumansInsulinInsulin ResistanceMaleBiomarkersBlood GlucoseInsulinPCSK9 protein, humanProprotein Convertase 9AdolescentsDyslipidemiaNutritional TherapyObesityPCSK9

Identifiers

PMID28228332
PMCPMC5410867
OpenAlexW2568081090

What Socratic holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.