ReviewMolecular genetics and genomics : MGG2017
Population structure and infectious disease risk in southern Africa.
Review in Molecular genetics and genomics : MGG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Human genetic ancestry,eLife · 2026Article
- Challenges of Diagnosing Mendelian Susceptibility to Mycobacterial Diseases in South Africa.International journal of molecular sciences · 2023Review
- The immunogenetics of tuberculosis (TB) susceptibility.Immunogenetics · 2023Review
- The recombination landscape of the Khoe-San likely represents the upper limits of recombination divergence in humans.Genome biology · 2022Article
- GWAS in the southern African context.PloS one · 2022Article
- African Genetic Representation in the Context of SARS-CoV-2 Infection and COVID-19 Severity.Frontiers in genetics · 2022Article
- Bantu-speaker migration and admixture in southern Africa.Human molecular genetics · 2021Review
- Inferring recombination patterns in African populations.Human molecular genetics · 2021Review
- Diabetes Risk Data Mining Method Based on Electronic Medical Record Analysis.Journal of healthcare engineering · 2021Article
- Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci.Frontiers in genetics · 2021Article
- Prospective avenues for human population genomics and disease mapping in southern Africa.Molecular genetics and genomics : MGG · 2020Review
- The critical needs and challenges for genetic architecture studies in Africa.Current opinion in genetics & development · 2018Review
- African genetic diversity provides novel insights into evolutionary history and local adaptations.Human molecular genetics · 2018Review
- Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Genetic Resistance toFrontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The KhoeSan populations are the earliest known indigenous inhabitants of southern Africa. The relatively recent expansion of Bantu-speaking agropastoralists, as well as European colonial settlement along the south-west coast, dramatically changed patterns of genetic diversity in a region which had been largely isolated for thousands of years. Owing to this unique history, population structure in southern Africa reflects both the underlying KhoeSan genetic diversity as well as differential recent admixture. This population structure has a wide range of biomedical and sociocultural implications; such as changes in disease risk profiles. Here, we consolidate information from various population genetic studies that characterize admixture patterns in southern Africa with an aim to better understand differences in adverse disease phenotypes observed among groups. Our review confirms that ancestry has a direct impact on an individual's immune response to infectious diseases. In addition, we emphasize the importance of collaborative research, especially for populations in southern Africa that have a high incidence of potentially fatal infectious diseases such as HIV and tuberculosis.
Indexed as
Identifiers
28229227What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.