Evidence map›Paper›PMID 28235828›Full record

ArticleG3 (Bethesda, Md.)2017

Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants.

Michela Traglia, Lisa A Croen, Kristen Lyall, Gayle C Windham, Marty Kharrazi, Gerald N DeLorenze, Anthony R Torres, Lauren A Weiss

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Michela TragliaDepartment of Psychiatry, Weill Institute for Neurosciences and Institute for Human Genetics, University of California, San Francisco, California 94143.ORCID 0000-0002-5700-135X
Lisa A CroenAutism Research Program, Division of Research, Kaiser Permanente, Oakland, California 94612.
Kristen LyallDivision of Environmental and Occupational Disease Control, California Department of Public Health, Richmond, California 94804.
Gayle C WindhamDivision of Environmental and Occupational Disease Control, California Department of Public Health, Richmond, California 94804.
Marty KharraziGenetic Disease Screening Program, California Department of Public Health, Richmond, California 94804.
Gerald N DeLorenzeAutism Research Program, Division of Research, Kaiser Permanente, Oakland, California 94612.
Anthony R TorresCenter for Persons with Disabilities, Utah State University, Logan, Utah 84322.
Lauren A WeissDepartment of Psychiatry, Weill Institute for Neurosciences and Institute for Human Genetics, University of California, San Francisco, California 94143 Lauren.Weiss@ucsf.edu.
California Department of Public Health · USKaiser Permanente · USUniversity of California, San Francisco · USUtah State University · US

Funding

Prenatal and Neonatal Biologic Markers for AutismR01ES016669 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI CROEN, LISA A · 2010 to 2014
$3.5M
NIEHS NIH HHS R01 ES016669
6 · The paper itself

Abstract

Maternal exposure to environmental pollutants could affect fetal brain development and increase autism spectrum disorder (ASD) risk in conjunction with differential genetic susceptibility. Organohalogen congeners measured in maternal midpregnancy blood samples have recently shown significant, but negative associations with offspring ASD outcome. We report the first large-scale maternal and fetal genetic study of the midpregnancy serum levels of a set of 21 organohalogens in a subset of 790 genotyped women and 764 children collected in California by the Early Markers for Autism (EMA) Project. Levels of PCB (polychlorinated biphenyl) and PBDE (polybrominated diphenyl ether) congeners showed high maternal and fetal estimated SNP-based heritability (

Indexed as

Maternal ExposureAutism Spectrum DisorderEnvironmental PollutantsFemaleFetusGenetic LociGenome-Wide Association StudyHumansInfant, NewbornInheritance PatternsLinear ModelsLinkage DisequilibriumPolymorphism, Single NucleotidePregnancyEnvironmental Pollutantsautism spectrum disordersenvironmental pollutantsGWASheritabilitymetabolismorganohalogens

Identifiers

PMID28235828
PMCPMC5386877
OpenAlexW2589427809

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.