Evidence map›Paper›PMID 28239487›Full record

ArticleEuropean heart journal. Quality of care & clinical outcomes2015

Angina Frequency After Acute Myocardial Infarction In Patients Without Obstructive Coronary Artery Disease.

Anna Grodzinsky, Suzanne V Arnold, Kensey Gosch, John A Spertus, JoAnne M Foody, John Beltrame, Thomas M Maddox, Susmita Parashar, Mikhail Kosiborod

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Quality of care & clinical outcomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05122780 phase4unknown statusstarted 2021, after this paper: background citation

PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial.

Ran2021Enrolled120Registered outcomes17Posted comparisons0ConditionsMyocardial Infarction With Non-Obstructive Coronary ArteriesArmsACEi/ARB, Acetylcholine provocative test, Anticoagulant, Antiplatelet Drug, Beta Blocker
PMID 30772224PMID 32628045PMID 31709984PMID 31270616PMID 30913893PMID 25587100PMID 30343094PMID 30266608PMID 29954744PMID 29228159PMID 28624816PMID 28476516other papers from this trial
Open the trial in the graph
NCT04186676 completednot on this mapstarted 2021, after this paper: background citation

Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population: Diagnosis and Management (The MINOCA-GR Registry)

Typeobservational_patient_registrySponsorAHEPA University HospitalRan2021 to 2024Enrolled60ConditionsAcute Myocardial Infarction, Non-Obstructive Coronary Atherosclerosis, Ischemic Heart Disease, Angina PectorisArmsMINOCA registry, CCTA Phenotypes
NCT04681612 unknown statusnot on this mapstarted 2019, after this paper: background citation

The Prognostic Role of Indices of Sympathetic Nervous System Overdrive in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries

Typeobservational_patient_registrySponsorHippocration General HospitalRan2019 to 2023Enrolled150ConditionsMyocardial Infarction With Nonobstructive Coronary ArteriesArmsMSNA, Heart Rate Variability, Blood Pressure Variability, CMR, History, Lab, clinical and hemodynamic parameters
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Microvascular Dysfunction in MINOCA: Still a Moving Target.Journal of the American Heart Association · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Myocardial Infarction with Nonobstructive Coronary Artery Disease-Definition, Etiopathogenesis, Diagnosis, and Management.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. MINOCA and INOCA: Role in Heart Failure.Current heart failure reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna GrodzinskySaint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO.
Suzanne V ArnoldSaint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO.
Kensey GoschSaint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO.
John A SpertusSaint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO.
JoAnne M FoodyDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA.
John BeltrameThe Queen Elizabeth Hospital Discipline of Medicine University of Adelaide and the Central Adelaide Local Health Network Cardiology Stream.
Thomas M MaddoxVA Eastern Colorado Health Care System, Denver, CO; University of Colorado School of Medicine, Denver, CO.
Susmita ParasharDivision of Cardiology, Department of Medicine, Emory University, Atlanta, GA.
Mikhail KosiborodSaint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO.

Funding

SCCOR in Cardiac Dysfunction and DiseaseP50HL077113 · WASHINGTON UNIVERSITY · 2005 to 2005
$2.8M
CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAMT32HL110837 · NHLBI · UNIVERSITY OF MISSOURI KANSAS CITY · 2022 to 2025
$910k
NHLBI NIH HHS P50 HL077113NHLBI NIH HHS T32 HL110837
6 · The paper itself

Abstract

backgroundMyocardial infarction (MI) patients without obstructive coronary artery disease (CAD) are at increased risk for recurrent ischemic events, but angina frequency post-MI has not been described. METHODS AND

resultsAmong MI patients who underwent angiography, we assessed angina at baseline, 1, 6, and 12 months using the Seattle Angina Questionnaire (SAQ). A hierarchical repeated measures modified Poisson model assessed the association between the absence of obstructive CAD (defined as epicardial stenoses >70% or left main >50%) and angina. Among 5539 MI patients from 31 US hospitals (mean age 60, 68% male), 6.9% had no angiographic obstructive CAD. More patients without obstructive CAD (vs. obstructive CAD) were female (57% vs 30%), non-white (51% vs 24%) and had NSTEMI (87% vs 51%). In unadjusted analyses, patients without obstructive CAD had less angina prior to MI but more angina and worse health status post-discharge. After adjustment for socio-demographic and clinical factors, the risk of post-MI angina was similar in patients without vs. with obstructive CAD (IRR=0.89, 95% CI 0.77-1.02). Among patients without obstructive CAD, depression and self-reported avoidance of care due to cost were independently associated with angina (IRR=1.28 per 5 points on PHQ, 95% CI 1.17-1.41; IRR=1.34, 95% 1.02-1.1.74).

conclusionsFollowing MI, patients without obstructive CAD experience an angina burden at least as high as those with obstructive CAD, affecting 1 in 4 patients at 12 months. As these patients are not candidates for revascularization, other anti-anginal strategies are needed to improve their health status and quality of life.

Indexed as

Acute myocardial infarctionAnginaCoronary artery disease

Identifiers

PMID28239487
PMCPMC5321550

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.