Evidence map›Paper›PMID 28248310›Full record

ArticleNature communications2017

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.

Martin S Davey, Carrie R Willcox, Stephen P Joyce, Kristin Ladell, Sofya A Kasatskaya, James E McLaren, Stuart Hunter, Mahboob Salim, Fiyaz Mohammed, David A Price and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 279 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. T Cell Thoughts.Immunological reviews · 2026
    Review
  8. Article
  9. Article
  10. Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function.bioRxiv : the preprint server for biology · 2026
    Article
  11. γδ T cells show distinct responses to CMV after stem cell transplantation.Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  12. Article
  13. Oligoclonal expansion of atypical Vδ2Nature communications · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Martin S DaveyCancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Carrie R WillcoxCancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Stephen P JoyceCancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Sofya A KasatskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.
James E McLarenDivision of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Stuart HunterCancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Mahboob SalimCancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Fiyaz MohammedCancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Dmitriy M ChudakovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.
Benjamin E WillcoxCancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
University of Birmingham · GBCardiff University · GBPirogov Russian National Research Medical University · RU

Funding

Medical Research Council G9818340
6 · The paper itself

Abstract

γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2

Indexed as

Immunologic SurveillanceAdultBiomarkersCell DifferentiationCell ProliferationClone CellsComplementarity Determining RegionsCX3C Chemokine Receptor 1Cytotoxicity, ImmunologicGenetic VariationHumansInterleukin-15PhenotypeReceptors, Antigen, T-Cell, gamma-deltaTissue DonorsTumor Necrosis Factor Receptor Superfamily, Member 7BiomarkersComplementarity Determining RegionsCX3C Chemokine Receptor 1CX3CR1 protein, humanInterleukin-15Receptors, Antigen, T-Cell, gamma-deltaTumor Necrosis Factor Receptor Superfamily, Member 7

Identifiers

PMID28248310
PMCPMC5337994
OpenAlexW2593493913

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.