ReviewFrontiers in immunology2017
T Cell Subpopulations in Healthy Elderly and Lung Cancer Patients: Insights from Cuban Studies.
Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Human immunodeficiency virus infection and mortality risk among lung cancer patients: A systematic review and meta-analysis.Medicine · 2018Pooled it
- T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy.Signal transduction and targeted therapy · 2026Review
- Multivariate analysis of immunosenescence data in healthy humans and diverse diseases.Frontiers in aging · 2025Article
- Assessment of changes in immune status linked to COVID-19 convalescent and its clinical severity in patients and uninfected exposed relatives.Immunobiology · 2022Article
- Persistent Changes of Peripheral Blood Lymphocyte Subsets in Patients with Oral Squamous Cell Carcinoma.Healthcare (Basel, Switzerland) · 2022Article
- The Effects of the Uncontrolled Use of Biomodulina T on the Severity of Severe Acute Respiratory Syndrome-Coronavirus 2 Infection in Older Cuban Adults: An Open Label Evaluation.Current therapeutic research, clinical and experimental · 2022Article
- Safety of Immune Checkpoint Inhibitors in Elderly Patients: An Observational Study.Current oncology (Toronto, Ont.) · 2021Observational
- Cognitive impairment is related to a reduced count of T-lymphocytes in older patients diagnosed with non-small cell lung cancer (NSCLC).Translational cancer research · 2020Article
- The Confounders of Cancer Immunotherapy: Roles of Lifestyle, Metabolic Disorders and Sociological Factors.Cancers · 2020Review
- CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function.Frontiers in immunology · 2020Article
- Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.Immunity & ageing : I & A · 2020Article
- Recovery of central memory and naive peripheral T cells in Follicular Lymphoma patients receiving rituximab-chemotherapy based regimen.Scientific reports · 2019Article
- Cytokine release syndrome after radiation therapy: case report and review of the literature.Journal for immunotherapy of cancer · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The senescence of the immune system and the risk of cancer increase with aging. Age itself entails changes in the immune system, which are related to a decrease in thymic output of naïve lymphocytes, an accumulation of chronic antigenic load, notably chronic viral infections such as cytomegalovirus (CMV), and replicative senescence of lymphocytes. These changes could eventually contribute to cancer risk and affect the response to cancer treatment. However, several confounding factors make it difficult to draw a picture of causal relationships. Studies in diverse human populations could contribute to clarify these complex relationships. Here, we summarize the current knowledge about the senescence of the T cells, the relationship with CMV infection, cancer, and cancer treatment. We also review the results of a series of studies performed in Cuba whose population is characterized by the unusual combination of long life expectancy and high antigenic load, including high seroprevalence of CMV, typical of tropical countries. Although immunosenescence affects almost all components and functions of the immune response, its most salient feature is a decrease in numbers and proportions of naïve CD8
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.