← Metformin × all-cause mortality

Observational studyMedicine2017

No association between metformin use and survival in patients with pancreatic cancer: An observational cohort study.

Martine A Frouws et al.PubMed ↗Full text ↗Publisher ↗

  • Metformin usersno clear effectNo clear link with overall survival.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation · may be no link

No clear link with overall survival

−14%−34% to +11%

metformin users vs nonusers

Bigger than 4 in 10 for all-cause mortality

As reported

IRR 0.86, 95% CI 0.66–1.11

Correlation · may be no link

No clear link with overall survival

−10%−41% to +40%

metformin users vs sulfonylurea derivatives users

Bigger than 3 in 10 for all-cause mortality

As reported

IRR 0.90, 95% CI 0.59–1.40

Who was studied, and how

1,111people with type 2 diabetes, in this paper

Already taking metformin users, or nottheir own situation, not assigned

on metformin users
nonusers

No clear link with overall survival−14%

correlation, not a test

the abstract, start to end

… for metformin users versus nonusers was 0.86 (95% CI: 0.66-1.11; P = 0.25).

… users showed an adjusted rate ratio of 0.90 (95% CI: 0.59-1.40; …

← favours treatmentfavours comparator →
could be chance
Overall survivalmetformin users vs nonusers
IRR 0.860.66–1.11
Overall survivalmetformin users vs sulfonylurea derivatives users
IRR 0.900.59–1.40
MetforminAll-cause mortality
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10 papers cite it

2017
2018
2019
2020
2021
2022
this paperpooled itcites it
Full record →Abstract, authors, funding and every citing paper · PMID 28272215