Evidence map›Paper›PMID 28278231›Full record

ArticlePloS one2017

The human plasma-metabolome: Reference values in 800 French healthy volunteers; impact of cholesterol, gender and age.

Séverine Trabado, Abdallah Al-Salameh, Vincent Croixmarie, Perrine Masson, Emmanuelle Corruble, Bruno Fève, Romain Colle, Laurent Ripoll, Bernard Walther, Claire Boursier-Neyret and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05434481 (MITAORTA - Role of Mitochondrial Dynamic in Aneurysm and Dissection of Ascending Thoracic Aorta), which is not on this map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05434481 naunknown statusnot on this mapstarted 2022, after this paper: background citation

MITAORTA - Role of Mitochondrial Dynamic in Aneurysm and Dissection of Ascending Thoracic Aorta

TypeinterventionalSponsorUniversity Hospital, AngersRan2022 to 2024Enrolled60ConditionsAortic Aneurysm and DissectionArmsMitochondrial dynamic analysis in the aorta samples and metabolomic profiling in the aortic diseases
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 154 citations in OpenAlex.

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  5. Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Trial
  6. Trial
  7. Impact of Daily Rhythms and Postprandial Responses on the Plasma Metabolome.International journal of molecular sciences · 2026
    Article
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  14. Review
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  19. Observational
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Séverine TrabadoAssistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Le Kremlin Bicêtre, France.ORCID http://orcid.org/0000-0002-1925-1999
Abdallah Al-SalamehAssistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin Bicêtre, France.
Vincent CroixmarieInstitut de Recherches Internationales Servier, Suresnes, France.
Perrine MassonTechnologie Servier, Orléans, France.
Emmanuelle CorrubleUniv Paris Sud, INSERM UMR 1178, Service de Psychiatrie, équipe "Dépression et Antidépresseurs", Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France.
Bruno FèveUPMC Univ Paris 06, INSERM UMR S938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Paris, France.
Romain ColleUniv Paris Sud, INSERM UMR 1178, Service de Psychiatrie, équipe "Dépression et Antidépresseurs", Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France.
Laurent RipollInstitut de Recherches Internationales Servier, Suresnes, France.
Bernard WaltherTechnologie Servier, Orléans, France.
Claire Boursier-NeyretTechnologie Servier, Orléans, France.
Erwan WernerTechnologie Servier, Orléans, France.
Laurent BecquemontDépartement de Pharmacologie, Faculté de médecine Paris-Sud, Université Paris-Sud, UMR 1184, CEA, DSV/iMETI, Division d'Immuno-Virologie, IDMIT, INSERM Centre d'Immunologie des Infections virales et des Maladies Autoimmunes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
Philippe ChansonInserm U1185, Fac Med Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Inserm · FRLaboratoire de Mathématiques Analyse, Probabilités, Modélisation Orléans · FRServier (France) · FRAssistance Publique – Hôpitaux de Paris · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolomic approaches are increasingly used to identify new disease biomarkers, yet normal values of many plasma metabolites remain poorly defined. The aim of this study was to define the "normal" metabolome in healthy volunteers. We included 800 French volunteers aged between 18 and 86, equally distributed according to sex, free of any medication and considered healthy on the basis of their medical history, clinical examination and standard laboratory tests. We quantified 185 plasma metabolites, including amino acids, biogenic amines, acylcarnitines, phosphatidylcholines, sphingomyelins and hexose, using tandem mass spectrometry with the Biocrates AbsoluteIDQ p180 kit. Principal components analysis was applied to identify the main factors responsible for metabolome variability and orthogonal projection to latent structures analysis was employed to confirm the observed patterns and identify pattern-related metabolites. We established a plasma metabolite reference dataset for 144/185 metabolites. Total blood cholesterol, gender and age were identified as the principal factors explaining metabolome variability. High total blood cholesterol levels were associated with higher plasma sphingomyelins and phosphatidylcholines concentrations. Compared to women, men had higher concentrations of creatinine, branched-chain amino acids and lysophosphatidylcholines, and lower concentrations of sphingomyelins and phosphatidylcholines. Elderly healthy subjects had higher sphingomyelins and phosphatidylcholines plasma levels than young subjects. We established reference human metabolome values in a large and well-defined population of French healthy volunteers. This study provides an essential baseline for defining the "normal" metabolome and its main sources of variation.

Indexed as

MetabolomeAdolescentAdultAgedAged, 80 and overAge FactorsBiomarkersCholesterolCross-Sectional StudiesFemaleFranceHealthy VolunteersHumansMaleMetabolomicsMiddle AgedBiomarkersCholesterol

Identifiers

PMID28278231
PMCPMC5344496
OpenAlexW2593664196

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.