Trial reportJACC. Cardiovascular imaging2017
Carotid Plaque Lipid Content and Fibrous Cap Status Predict Systemic CV Outcomes: The MRI Substudy in AIM-HIGH.
Trial report in JACC. Cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00880178. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
Open the trial in the graphWho cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Meta-Analysis of Intensive Lipid-Lowering Therapy in Patients With Polyvascular Disease.Journal of the American Heart Association · 2021Pooled it
- Assessment of Therapeutic Response to Statin Therapy in Patients With Intracranial or Extracranial Carotid Atherosclerosis by Vessel Wall MRI: A Systematic Review and Updated Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Diagnostic performance of MRI for detecting intraplaque hemorrhage in the carotid arteries: a meta-analysis.European radiology · 2019Pooled it
- Burden of Atherosclerosis and Outcomes of Acute Pulmonary Embolism: A Post Hoc Analysis of the Hokusai-VTE Trial.Journal of the American Heart Association · 2025Trial
- Magnetic Resonance Imaging of Intraplaque Hemorrhage and Plaque Lipid Content With Continued Lipid-Lowering Therapy: Results of a Magnetic Resonance Imaging Substudy in AIM-HIGH.Circulation. Cardiovascular imaging · 2022Trial
- Non-stenotic Carotid Disease: Review of the Literature and Case Discussion of TCAR for Treatment.Seminars in neurology · 2026Review
- Plaque-level machine-learning prediction of carotid plaque vulnerability on computed tomography angiography.Neuroradiology · 2026Article
- Distribution of high-resolution magnetic resonance imaging -based carotid Plaque-RADS subtypes among patients with acute cerebral infarction.Neuroradiology · 2026Article
- Carotid Plaque-RADS improves preoperative coronary risk stratification in candidates for carotid revascularization.Insights into imaging · 2026Article
- Evaluating Carotid Plaque Stiffness with Ultrasound 2D Shear-Wave Elastography in Patients Undergoing Coronary Artery Bypass Grafting.Diagnostics (Basel, Switzerland) · 2025Article
- Non-alcoholic fatty liver disease is a strong predictor of carotid high-risk plaques as assessed by high-resolution magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Evaluation of risk factors for acute stroke using combined CTA and MR HR-VWI imaging.Frontiers in neurology · 2025Review
- Serum chemokines combined with multi-modal imaging to evaluate atherosclerotic plaque stability in patients undergoing carotid endarterectomy.Frontiers in neurology · 2025Article
- Combining Computational Fluid Dynamics, Structural Analysis, and Machine Learning to Predict Cerebrovascular Events: A Mild ML Approach.Diagnostics (Basel, Switzerland) · 2024Article
- Near-infrared multispectral photoacoustic analysis of lipids and intraplaque hemorrhage in human carotid artery atherosclerosis.Photoacoustics · 2024Article
- Comparison of the diagnostic performance of contrast-enhanced ultrasound and high-resolution magnetic resonance imaging in the evaluation of histologically defined vulnerable carotid plaque: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2024Article
- Associations of genetically predicted vitamin D status and deficiency with the risk of carotid artery plaque: a Mendelian randomization study.Scientific reports · 2024Article
- The value of coordinated analysis of multimodal atherosclerotic plaque imaging in the assessment of cardiovascular and cerebrovascular events.Frontiers in cardiovascular medicine · 2024Article
- [Correlations between plaque characteristics and cerebral blood flow in patients with moderate to severe carotid stenosis using magnetic resonance vessel wall imaging].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
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Authors and funding
15 authors.
Funding
Abstract
objectivesThe aim of this study was to investigate whether and what carotid plaque characteristics predict systemic cardiovascular outcomes in patients with clinically established atherosclerotic disease.
backgroundAdvancements in atherosclerosis imaging have allowed assessment of various plaque characteristics, some of which are more directly linked to the pathogenesis of acute cardiovascular events compared to plaque burden.
methodsAs part of the event-driven clinical trial AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes), subjects with clinically established atherosclerotic disease underwent multicontrast carotid magnetic resonance imaging (MRI) to detect plaque tissue composition and high-risk features. Prospective associations between MRI measurements and the AIM-HIGH primary endpoint (fatal and nonfatal myocardial infarction, ischemic stroke, hospitalization for acute coronary syndrome, and symptom-driven revascularization) were analyzed using Cox proportional hazards survival models.
resultsOf the 232 subjects recruited, 214 (92.2%) with diagnostic image quality constituted the study population (82% male, mean age 61 ± 9 years, 94% statin use). During median follow-up of 35.1 months, 18 subjects (8.4%) reached the AIM-HIGH endpoint. High lipid content (hazard ratio [HR] per 1 SD increase in percent lipid core volume: 1.57; p = 0.002) and thin/ruptured fibrous cap (HR: 4.31; p = 0.003) in carotid plaques were strongly associated with the AIM-HIGH endpoint. Intraplaque hemorrhage had a low prevalence (8%) and was marginally associated with the AIM-HIGH endpoint (HR: 3.00; p = 0.053). High calcification content (HR per 1 SD increase in percent calcification volume: 0.66; p = 0.20), plaque burden metrics, and clinical risk factors were not significantly associated with the AIM-HIGH endpoint. The associations between carotid plaque characteristics and the AIM-HIGH endpoint changed little after adjusting for clinical risk factors, plaque burden, or AIM-HIGH randomized treatment assignment.
conclusionsAmong patients with clinically established atherosclerotic disease, carotid plaque lipid content and fibrous cap status were strongly associated with systemic cardiovascular outcomes. Markers of carotid plaque vulnerability may serve as novel surrogate markers for systemic atherothrombotic risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.