Evidence map›Paper›PMID 28283572›Full record

ArticleThe Journal of biological chemistry2017

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.

Boyoung Cha, Jianbo Yang, Varsha Singh, Nicholas C Zachos, Rafiquel I Sarker, Tian-E Chen, Molee Chakraborty, Chung-Ming Tse, Mark Donowitz

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated CaAmerican journal of physiology. Gastrointestinal and liver physiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Boyoung ChaDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Jianbo YangDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Varsha SinghDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Nicholas C ZachosDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Rafiquel I SarkerDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Tian-E ChenDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Molee ChakrabortyDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Chung-Ming TseDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Mark DonowitzDepartments of Physiology and Medicine, Gastroenterology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. Electronic address: mdonowit@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Two-Photon Microscopy Imaging CoreP01DK072084 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2006 to 2013
$12.7M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
DIARRHEAL DISEASES: A PHYSIOLOGIC APPROACH TO TREATMENTR01DK026523 · NIDDK · TUFTS MEDICAL CENTER · PI DONOWITZ, MARK · 1986 to 2016
$7.8M
PDZ Domain Proteins and NHE3 RegulationR01DK061765 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK, TSE, CHUNG-MING · 2004 to 2013
$4.7M
NIDDK NIH HHS P01 DK072084NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK026523NIDDK NIH HHS R01 DK061765
6 · The paper itself

Abstract

NHE3 directly binds Na

Indexed as

Amino Acid MotifsCalciumCell LineCell MembraneCyclic GMPHumansMutationPDZ DomainsPhosphoproteinsProtein BindingProtein StabilitySodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersCalciumCyclic GMPPhosphoproteinsSLC9A3 protein, humanSodium-Hydrogen Exchanger 3sodium-hydrogen exchanger regulatory factorSodium-Hydrogen Exchangerscalciumepithelial cellNHE3PDZ domainsodium-proton exchangesodium transport

Identifiers

PMID28283572
PMCPMC5437235
OpenAlexW2591860688

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.