Evidence map›Paper›PMID 28289928›Full record

ArticleVirus genes2017

Human rotavirus strain Wa downregulates NHE1 and NHE6 expressions in rotavirus-infected Caco-2 cells.

Honglang Chen, Lijun Song, Guixian Li, Wenfeng Chen, Shumin Zhao, Ruoxia Zhou, Xiaoying Shi, Zhenying Peng, Wenchang Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. The Preparation of Gen-NHPharmaceutics · 2022
    Article
  4. Article
  5. Review
  6. (Patho-)Physiology of NaFrontiers in physiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Honglang ChenSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China.
Lijun SongSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China.
Guixian LiDepartment of Pathology, School of Basic Medicine, Guangdong Medical University, Dongguan, 523808, Guangdong Province, China.
Wenfeng ChenSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China.
Shumin ZhaoSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China.
Ruoxia ZhouSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China.
Xiaoying ShiSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China.
Zhenying PengSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China.
Wenchang ZhaoSchool of Pharmacy, Guangdong Medical University, No. 1, Xincheng Road of Songshan Lake Science and Technology Industry Park, Dongguan, 523808, Guangdong Province, China. zhaowenchang@126.com.
Guangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rotavirus (RV) is the most common cause of severe gastroenteritis and fatal dehydration in human infants and neonates of different species. However, the pathogenesis of rotavirus-induced diarrhea is poorly understood. Secretory diarrhea caused by rotavirus may lead to a combination of excessive secretion of fluid and electrolytes into the intestinal lumen. Fluid absorption in the small intestine is driven by Na

Indexed as

Down-RegulationAnimalsCaco-2 CellsCalciumCalcium-Calmodulin-Dependent Protein KinasesCalmodulinCell LineCytosolDiarrheaGene Expression RegulationHumansMacaca mulattaRNA, MessengerRotavirusRotavirus InfectionsSodium-Hydrogen Exchanger 1CalciumCalcium-Calmodulin-Dependent Protein KinasesCalmodulinRNA, MessengerSLC9A1 protein, humanSLC9A6 protein, humanSLC9A8 protein, humanSodium-Hydrogen Exchanger 1Sodium-Hydrogen ExchangersMechanismNHE1NHE6NHEsRotavirusRotavirus-induced diarrhea

Identifiers

PMID28289928
OpenAlexW2595704195

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.