Evidence map›Paper›PMID 28298895›Full record

ArticleFrontiers in physiology2017

Two Phase Modulation of [Formula: see text] Entry and Cl

Minjeong Ji, Chul-Kyu Park, Jin Woo Lee, Kook Yang Park, Kuk Hui Son, Jeong Hee Hong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Minjeong JiDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon UniversityIncheon, South Korea.
Chul-Kyu ParkDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon UniversityIncheon, South Korea.
Jin Woo LeeDepartment of Molecular Medicine, School of Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon UniversityIncheon, South Korea.
Kook Yang ParkDepartment of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon UniversityIncheon, South Korea.
Kuk Hui SonDepartment of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon UniversityIncheon, South Korea.
Jeong Hee HongDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon UniversityIncheon, South Korea.
Gachon University · KRGachon University Gil Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dexmedetomidine (Dex), a highly selective α2-adrenoceptor agonist, attenuates inflammatory responses induced by lipopolysaccharide (LPS) and induces sedative and analgesic effects. Administration of Dex also reduces salivary secretion in human subjects and inhibits osmotic water permeability in rat cortical collecting ducts. However, little is known about the mechanisms underlying the effects of Dex on salivary glands fluid secretion. We demonstrated the α2-adrenoceptor expression in the basolateral membrane of mouse submandibular glands (SMG). To investigate fluid secretion upon treatment with Dex, we studied the effects of Dex on the activity of Na

Indexed as

dexmedetomidineion transportersphosphodiesterase 4secretionsubmandibular gland

Identifiers

PMID28298895
PMCPMC5331071
OpenAlexW2592039065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.