Evidence map›Paper›PMID 28298931›Full record

ReviewStem cells international2017

The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche.

Amer Youssef, Doaa Aboalola, Victor K M Han

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 140 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. A spatially organizedScience advances · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Amer YoussefDepartment of Biochemistry, Western University, London, ON, Canada; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Children's Health Research Institute, Western University, London, ON, Canada; Lawson Health Research Institute, Western University, London, ON, Canada.ORCID 0000-0002-8558-9488
Doaa AboalolaChildren's Health Research Institute, Western University, London, ON, Canada; Lawson Health Research Institute, Western University, London, ON, Canada; Department of Anatomy and Cell Biology, Western University, London, ON, Canada; King Abdullah International Medical Research Center, National Guard Health Affairs, Jeddah, Saudi Arabia.
Victor K M HanDepartment of Biochemistry, Western University, London, ON, Canada; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Children's Health Research Institute, Western University, London, ON, Canada; Lawson Health Research Institute, Western University, London, ON, Canada; Department of Anatomy and Cell Biology, Western University, London, ON, Canada.ORCID 0000-0003-3479-9132
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue regeneration therapies. However, the MSC availability in most tissues is limited which demands expansion in vitro following isolation. Like many developing cells, the state of MSCs is affected by the surrounding microenvironment, and mimicking this natural microenvironment that supports multipotent or differentiated state in vivo is essential to understand for the successful use of MSC in regenerative therapies. Many researchers are, therefore, optimizing cell culture conditions in vitro by altering growth factors, extracellular matrices, chemicals, oxygen tension, and surrounding pH to enhance stem cells self-renewal or differentiation. Insulin-like growth factors (IGFs) system has been demonstrated to play an important role in stem cell biology to either promote proliferation and self-renewal or enhance differentiation onset and outcome, depending on the cell culture conditions. In this review, we will describe the importance of IGFs, IGF-1 and IGF-2, in development and in the MSC niche and how they affect the pluripotency or differentiation towards multiple lineages of the three germ layers.

Identifiers

PMID28298931
PMCPMC5337393
OpenAlexW2588078241

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.