ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2017
Heritability of brain activity related to response inhibition: A longitudinal genetic study in adolescent twins.
Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Trans-ancestry meta-analysis of genome wide association studies of inhibitory control.Molecular psychiatry · 2023Pooled it
- Electrophysiological characteristics in adolescents with non-suicidal self-injury: an event-related potential study and source analysis.Frontiers in psychiatry · 2025Article
- Improving accuracy and precision of heritability estimation in twin studies through hierarchical modeling: reassessing the measurement error assumption.Frontiers in genetics · 2025Article
- Neural indices of heritable impulsivity: Impact of the COMT Val158Met polymorphism on frontal beta power during early motor preparation.Biological psychology · 2024Article
- Shared genetic etiology between ADHD, task-related behavioral measures and brain activation during response inhibition in a youth ADHD case-control study.European archives of psychiatry and clinical neuroscience · 2024Article
- The known and unknown about attention deficit hyperactivity disorder (ADHD) genetics: a special emphasis on Arab population.Frontiers in genetics · 2024Review
- Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity.Brain and behavior · 2021Article
- GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals.Addictive behaviors · 2021Article
- Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth.Development and psychopathology · 2021Article
- Test-Retest Reliability of Neural Correlates of Response Inhibition and Error Monitoring: An fMRI Study of a Stop-Signal Task.Frontiers in neuroscience · 2021Article
- Effects of Acute Aerobic Exercise Combined with Resistance Exercise on Neurocognitive Performance in Obese Women.Brain sciences · 2020Article
- ADHD: Current Concepts and Treatments in Children and Adolescents.Neuropediatrics · 2020Review
- The Role of Parent Self-Regulation in Youth Type 1 Diabetes Management.Current diabetes reports · 2020Review
- A Model of Aggressive Behavior: Early Adversity, Impulsivity, and Response Inhibition.Journal of aggression, maltreatment & trauma · 2020Article
- [Response inhibition and emotional responding in attention-deficit/hyperactivity disorder with comorbid disruptive, impulse-control, and conduct disorders].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Article
- The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.Developmental cognitive neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ability to inhibit prepotent but context- or goal-inappropriate responses is essential for adaptive self-regulation of behavior. Deficits in response inhibition, a key component of impulsivity, have been implicated as a core dysfunction in a range of neuropsychiatric disorders such as ADHD and addictions. Identification of genetically transmitted variation in the neural underpinnings of response inhibition can help to elucidate etiological pathways to these disorders and establish the links between genes, brain, and behavior. However, little is known about genetic influences on the neural mechanisms of response inhibition during adolescence, a developmental period characterized by weak self-regulation of behavior. Here we investigated heritability of ERPs elicited in a Go/No-Go task in a large sample of adolescent twins assessed longitudinally at ages 12, 14, and 16. Genetic analyses showed significant heritability of inhibition-related frontal N2 and P3 components at all three ages, with 50 to 60% of inter-individual variability being attributable to genetic factors. These genetic influences included both common genetic factors active at different ages and novel genetic influences emerging during development. Finally, individual differences in the rate of developmental changes from age 12 to age 16 were significantly influenced by genetic factors. In conclusion, the present study provides the first evidence for genetic influences on neural correlates of response inhibition during adolescence and suggests that ERPs elicited in the Go/No-Go task can serve as intermediate neurophysiological phenotypes (endophenotypes) for the study of disinhibition and impulse control disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.