Evidence map›Paper›PMID 28318098›Full record

Trial reportDiabetes, obesity & metabolism2017

Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men.

Piryanka Motiani, Kirsi A Virtanen, Kumail K Motiani, Joonas J Eskelinen, Roeland J Middelbeek, Laurie J Goodyear, Anna M Savolainen, Jukka Kemppainen, Jørgen Jensen, Mueez U Din and 7 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. The Effects of 10-Week Strength Training in the Winter on Brown-like Adipose Tissue Vascular Density.International journal of environmental research and public health · 2022
    Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Exercise as a tool to mitigate metabolic disease.American journal of physiology. Cell physiology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Exercise-induced regulation of adipose tissue.Current opinion in genetics & development · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Piryanka MotianiTurku PET Centre, University of Turku, Turku, Finland.ORCID 0000-0002-2876-1851
Kirsi A VirtanenTurku PET Centre, University of Turku, Turku, Finland.
Kumail K MotianiTurku PET Centre, University of Turku, Turku, Finland.
Joonas J EskelinenTurku PET Centre, University of Turku, Turku, Finland.
Roeland J MiddelbeekSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Laurie J GoodyearSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Anna M SavolainenTurku PET Centre, University of Turku, Turku, Finland.
Jukka KemppainenTurku PET Centre, University of Turku, Turku, Finland.
Jørgen JensenDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Mueez U DinTurku PET Centre, University of Turku, Turku, Finland.
Virva SaunavaaraTurku PET Centre, University of Turku, Turku, Finland.
Riitta ParkkolaTurku PET Centre, University of Turku, Turku, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku, Turku, Finland.
Juhani KnuutiTurku PET Centre, Åbo Akademi University, Turku, Finland.
Pirjo NuutilaTurku PET Centre, University of Turku, Turku, Finland.
Kari K KalliokoskiTurku PET Centre, University of Turku, Turku, Finland.
Jarna C HannukainenTurku PET Centre, University of Turku, Turku, Finland.
University of Turku · FIJoslin Diabetes Center · USÅbo Akademi University · FINorwegian School of Sport Sciences · NO

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
TRAINING IN DIABETES AND METABOLISMT32DK007260 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$13.6M
Novel Mechanisms of Exercise Training Effects on Glucose HomeostasisR01DK099511 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 2014 to 2026
$6.5M
Exercise Regulation of Human Adipose TissueR01DK112283 · NIDDK · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 2016 to 2018
$1.2M
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK099511NIDDK NIH HHS R01 DK112283NIDDK NIH HHS T32 DK007260
6 · The paper itself

Abstract

aimsTo test the hypothesis that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) improve brown adipose tissue (BAT) insulin sensitivity. PARTICIPANTS AND

methodsHealthy middle-aged men (n = 18, age 47 years [95% confidence interval {CI} 49, 43], body mass index 25.3 kg/m

resultsTraining improved VO

conclusionsParticipants with functionally active BAT have an improved metabolic profile compared with those with low BAT activity. Short-term exercise training decreased insulin-stimulated BAT glucose uptake in participants with active BAT, suggesting that training does not work as a potent stimulus for BAT activation.

Indexed as

Adipose Tissue, BrownAdultExerciseFatty Acids, NonesterifiedGlucoseHealthHumansInsulinInsulin ResistanceMaleMiddle AgedMuscle, SkeletalOxygen ConsumptionFatty Acids, NonesterifiedGlucoseInsulinbrown adipose tissueexercise trainingfree fatty acid uptakeglucose uptakepositron emission tomography

Identifiers

PMID28318098
PMCPMC5607085
OpenAlexW2602474125

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.