SynthesisJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2017
The Association between Carotid Artery Atherosclerosis and Silent Brain Infarction: A Systematic Review and Meta-analysis.
Synthesis in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Automated Detection of Carotid Artery Stenosis Using a Sensitive Accelerometer Wearable Sensor and Interpretable Machine Learning.Biosensors · 2026Article
- Trajectories of total and domain-specific physical activity and vascular structure and function in mid-adulthood: the Childhood Determinants of Adult Health study.European heart journal open · 2026Article
- Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026Review
- A Review of Emerging Biomarkers Connecting Diabetes and Ischemic Stroke: Implications for Early Detection and Risk Stratification.Journal of diabetes research · 2026Review
- Cervical Internal Carotid Artery Plaque Composition and Chronic White Matter Disease in Patients with Noncardioembolic Stroke: A Multicenter Analysis.Stroke (Hoboken, N.J.) · 2025Article
- Role of Arterial Stiffness and Carotid Intima-Media Thickness on Subclinical Atherosclerosis and Cardiovascular Risk Assessment.Cardiology and therapy · 2025Review
- The study on risk assessment of carotid plaques in the Northern Chinese population based on LASSO regression.Scientific reports · 2025Article
- Mimicking aneurysm in a patient with chronic occlusion of the left middle cerebral artery.World journal of clinical cases · 2025Article
- Unstable Plaque is a Treatable Cause of Cognitive Decline.Medical hypotheses · 2024Article
- Intima-Media Thickness in the Carotid Bifurcation is Related to Silent Brain Infarction: A Cross-Sectional Study.Journal of atherosclerosis and thrombosis · 2024Article
- Predictability of Cardiovascular Risk Scores for Carotid Atherosclerosis in Community-Dwelling Middle-Aged and Elderly Adults.Journal of clinical medicine · 2024Article
- Interstitial flow, pressure and residual stress in the aging carotid artery model in FEBio.Biomechanics and modeling in mechanobiology · 2024Article
- Silent brain ischemia within the TAXINOMISIS framework: association with clinical and advanced ultrasound metrics.Frontiers in neurology · 2024Article
- Article
- Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition.Blood · 2023Article
- Associations of time-weighted individual exposure to ambient particulate matter with carotid atherosclerosis in Beijing, China.Environmental health : a global access science source · 2023Article
- Pulse wave and vector flow Imaging for atherosclerotic disease progression in hypercholesterolemic swine.Scientific reports · 2023Article
- Distribution Pattern Analysis of Cortical Brain Infarcts on Diffusion-Weighted Magnetic Resonance Imaging: A Hypothesis-Generating Approach to the Burden of Silent Embolic Stroke.Journal of the American Heart Association · 2022Article
- Evaluation of Intima-Media Thickness and Arterial Stiffness as Early Ultrasound Biomarkers of Carotid Artery Atherosclerosis.Cardiology and therapy · 2022Review
- The risk factors of old silent brain infarctions in carotid artery stenosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCarotid atherosclerosis is responsible for ~20% of ischemic strokes, but it is unclear whether carotid disease is associated with the presence of downstream silent brain infarction (SBI). We performed a systematic review and meta-analysis to study the relationship between SBI and 2 separate manifestations of carotid atherosclerosis, carotid intima-media thickening (IMT) and luminal stenosis.
methodsOvid MEDLINE, Ovid Embase, and the Cochrane Library Database were searched with an additional search of references and citing articles of target studies. Articles were included if they reported an association between carotid IMT or stenosis and magnetic resonance imaging-defined SBI, excluding SBIs found after carotid intervention.
resultsWe pooled 7 studies of carotid IMT reporting on 1469 subjects with SBI and 5102 subjects without SBI. Subjects with SBI had a larger mean IMT than subjects without SBI (pooled standardized mean difference, .37; 95% confidence interval [CI], .23-.51; P < .0001). We pooled 11 studies of carotid stenosis reporting on 12,347 subjects (2110 subjects with carotid stenosis and 10,237 subjects without carotid stenosis). We found a higher prevalence of SBI among subjects with carotid stenosis (30.4% versus 17.4%). Our pooled random-effects analysis showed a significant positive relationship between carotid stenosis and SBI (odds ratio, 2.78; 95% CI, 2.19-3.52; P < .0001).
conclusionsTwo forms of atherosclerotic disease, carotid IMT and stenosis, are both significantly associated with SBI. This review highlights a lack of consistent definitions for carotid disease measures and little evidence evaluating SBI prevalence downstream from carotid stenosis.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.