ArticleCardiovascular diabetology2017
Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes.
Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Understanding the relationship between sleep and quality of life in type 2 diabetes: A systematic review of the literature.Journal of health psychology · 2023Pooled it
- Association of the Coexistence of Somnipathy and Diabetes With the Risks of Cardiovascular Disease Events, Stroke, and All-Cause Mortality: A Systematic Review and Meta-analysis.Journal of the American Heart Association · 2022Pooled it
- Snoring Is Associated With Increased Risk of Stroke: A Cumulative Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Advances in cardiovascular risk assessment indicators in obstructive sleep apnea.Frontiers in public health · 2026Review
- Effects of obstructive sleep apnea on vascular structure and function in adults with obesity and type 2 diabetes: a comparative study.Cardiovascular endocrinology & metabolism · 2025Article
- Sleep apnea and daytime sleepiness in police officers from Kerala, India.BMC public health · 2025Article
- Type 2 Diabetes Mellitus and Obstructive Sleep Apnoea Syndrome in the Elderly.Healthcare (Basel, Switzerland) · 2025Article
- Article
- The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients.ERJ open research · 2025Article
- Impact of snoring on the risk of stroke in patients with diabetes mellitus.Sleep & breathing = Schlaf & Atmung · 2024Article
- Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population.The Lancet regional health. Western Pacific · 2024Article
- Review
- Impact of obstructive sleep apnea complicated with type 2 diabetes on long-term cardiovascular risks and all-cause mortality in elderly patients.BMC geriatrics · 2021Article
- Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice.Frontiers in cardiovascular medicine · 2021Article
- A dual blocker of endothelin A/B receptors mitigates hypertension but not renal dysfunction in a rat model of chronic kidney disease and sleep apnea.American journal of physiology. Renal physiology · 2019Article
- Obstructive Sleep Apnea in Children and Adolescents and the Risk of Major Adverse Cardiovascular Events: A Nationwide Cohort Study in Taiwan.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study.Cardiovascular diabetology · 2018Article
- Health-related quality of life in type 2 diabetes mellitus patients with different risk for obstructive sleep apnea.Patient preference and adherence · 2018Article
- Cardiorespiratory interaction with continuous positive airway pressure.Journal of thoracic disease · 2018Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnea (OSA) and type 2 diabetes (T2D) are associated with endothelial dysfunction a main predictor of late cardiovascular (CV) events. Despite the high prevalence of OSA in patients with T2D, the impact of OSA severity on endothelial function has not been clearly elucidated. The aim of this cross-sectional study was to determine whether increasing OSA severity is associated with poorer endothelial function in patients with T2D.
methods140 patients with T2D and no overt CV disease underwent polysomnography, peripheral arterial tonometry, clinic blood pressure (BP) measurement, biological assessment for CV risk factors, daytime sleepiness and health related quality of life (HRQL) questionnaires. The following commonly used cut-offs for apnea-hypopnea index (AHI) were used to define 3 categories of disease severity: AHI < 15 (no OSA or mild OSA), 15 ≤ AHI < 30 (moderate OSA), and AHI ≥ 30 (severe OSA). The primary outcome was the reactive hyperemia index (RHI), a validated assessment of endothelial function.
results21.4% of patients had moderate OSA and 47.6% had severe OSA. Increasing OSA severity and nocturnal hypoxemia were not associated with a significant decrease in RHI. Endothelial dysfunction (RHI < 1.67) was found in 47.1, 44.4 and 39.2% of patients with no OSA or mild OSA, moderate OSA and severe OSA, respectively (p = 0.76). After adjustment for confounders including body mass index, increasing OSA severity was associated with higher systolic BP (p = 0.03), lower circulating levels of adiponectin (p = 0.0009), higher levels of sP-selectin (p = 0.03), lower scores in 3 domains of HRQL including energy/vitality (p = 0.02), role functioning (p = 0.01), and social functioning (p = 0.04).
conclusionsModerate to severe OSA is very common but has no impact on digital micro-vascular endothelial function in patients with T2D.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.