Evidence map›Paper›PMID 28328397›Full record

ArticleeLife2017

Age-dependent diastolic heart failure in an in vivo

Matthew P Klassen, Christian J Peters, Shiwei Zhou, Hannah H Williams, Lily Yeh Jan, Yuh Nung Jan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The mTOR signaling pathway in cardiac aging.The journal of cardiovascular aging · 2023
    Article
  10. The opportunities and challenges of usingFrontiers in physiology · 2023
    Article
  11. Article
  12. Article
  13. Analysis ofAmerican journal of physiology. Heart and circulatory physiology · 2022
    Article
  14. Reduction ofFrontiers in cell and developmental biology · 2022
    Article
  15. Article
  16. Article
  17. Identification ofDisease models & mechanisms · 2020
    Article
  18. Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Article
  20. Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Matthew P KlassenDepartment of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-3633-2512
Christian J PetersDepartment of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.
Shiwei ZhouDepartment of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.
Hannah H WilliamsDepartment of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.
Lily Yeh JanDepartment of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.
Yuh Nung JanDepartment of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.
Howard Hughes Medical Institute · US

Funding

DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Genetic Dissection of Dendrite DevelopmentR37NS040929 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, YUH NUNG · 2010 to 2016
$2.5M
Howard Hughes Medical InstituteNIH HHS P40 OD010949NINDS NIH HHS R37 NS040929
6 · The paper itself

Abstract

While the signals and complexes that coordinate the heartbeat are well established, how the heart maintains its electromechanical rhythm over a lifetime remains an open question with significant implications to human health. Reasoning that this homeostatic challenge confronts all pulsatile organs, we developed a high resolution imaging and analysis toolset for measuring cardiac function in intact, unanesthetized

Indexed as

Drosophila melanogasterAnimalsDisease Models, AnimalHeart Failure, DiastolicHumansagingcardiac physiologycell biologyD. melanogasterion channels

Identifiers

PMID28328397
PMCPMC5362267
OpenAlexW2599739225

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.