ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Novel Orthopoxvirus Infection in an Alaska Resident.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 78 citations in OpenAlex.
- Assessment of three antiviral compounds against Borealpox virus infection in a mouse model.Emerging microbes & infections · 2026Article
- Engineered fluorescence for live diagnostics and quantification of poxvirus infection.The Journal of general virology · 2026Article
- Six Cases of Borealpox and Evidence of a Zoonotic Source: Alaska, 2020-2023.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Development and evaluation of a two-tube multiplex real-time PCR assay for differential detection of Monkeypox virus clades Ia, Ib, IIa, and IIb.Frontiers in microbiology · 2026Article
- Poxvirus Host-Range Determinants: SAMD9/9L and Beyond.Annual review of virology · 2025Review
- Fatal Borealpox in an Immunosuppressed Patient Treated With Antivirals and Vaccinia Immunoglobulin-Alaska, 2023.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Viral genomic features predict Orthopoxvirus reservoir hosts.Communications biology · 2025Article
- Poxvirus Epidemiology.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Viral genomic features predictbioRxiv : the preprint server for biology · 2024Article
- Camelpox Virus in Western Kazakhstan: Assessment of the Role of Local Fauna as Reservoirs of Infection.Viruses · 2024Article
- Human mpox: global trends, molecular epidemiology and options for vaccination.Pathogens and global health · 2024Review
- Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus.Frontiers in immunology · 2024Article
- Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus.Advances in experimental medicine and biology · 2024Review
- Monkeypox: A comprehensive review of a multifaceted virus.Infectious medicine · 2023Review
- Antiviral activities of two nucleos(t)ide analogs against vaccinia and mpox viruses in primary human fibroblasts.bioRxiv : the preprint server for biology · 2023Article
- The recent re-emergence of human monkeypox: Would it become endemic beyond Africa?Journal of infection and public health · 2023Review
- Monkeypox Virus Infections in Humans.Clinical microbiology reviews · 2022Review
- Genomic Sequencing and Phylogenomics of Cowpox Virus.Viruses · 2022Article
- Comparative Pathology of Zoonotic Orthopoxviruses.Pathogens (Basel, Switzerland) · 2022Review
- New p35 (H3L) Epitope Involved in Vaccinia Virus Neutralization and Its Deimmunization.Viruses · 2022Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND.: Human infection by orthopoxviruses is being reported with increasing frequency, attributed in part to the cessation of smallpox vaccination and concomitant waning of population-level immunity. In July 2015, a female resident of interior Alaska presented to an urgent care clinic with a dermal lesion consistent with poxvirus infection. Laboratory testing of a virus isolated from the lesion confirmed infection by an Orthopoxvirus. METHODS.: The virus isolate was characterized by using electron microscopy and nucleic acid sequencing. An epidemiologic investigation that included patient interviews, contact tracing, and serum testing, as well as environmental and small-mammal sampling, was conducted to identify the infection source and possible additional cases. RESULTS.: Neither signs of active infection nor evidence of recent prior infection were observed in any of the 4 patient contacts identified. The patient's infection source was not definitively identified. Potential routes of exposure included imported fomites from Azerbaijan via the patient's cohabiting partner or wild small mammals in or around the patient's residence. Phylogenetic analyses demonstrated that the virus represents a distinct and previously undescribed genetic lineage of Orthopoxvirus, which is most closely related to the Old World orthopoxviruses. CONCLUSIONS.: Investigation findings point to infection of the patient after exposure in or near Fairbanks. This conclusion raises questions about the geographic origins (Old World vs North American) of the genus Orthopoxvirus. Clinicians should remain vigilant for signs of poxvirus infection and alert public health officials when cases are suspected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.