ArticleAmerican journal of epidemiology2017
Risk of Diabetes After Hysterectomy With or Without Oophorectomy in Postmenopausal Women.
Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Menopause factors and alterations in gut microbiota and insulin homeostasis: A cross-sectional analysis of the microbiome and insulin longitudinal evaluation study (MILES).Diabetes, obesity & metabolism · 2025Article
- Education level is associated with the occurrence and timing of hysterectomy: A cohort study of Canadian women.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Association of hysterectomy with nonalcoholic fatty liver disease among US women.Lipids in health and disease · 2024Article
- Article
- Combined Therapy with Anthracyclines and GnRH Analogues for Breast Cancer: Impact on Ischemic Heart Disease.Journal of clinical medicine · 2023Review
- Hysterectomy With and Without Oophorectomy, Tubal Ligation, and Risk of Cardiovascular Disease in the Nurses' Health Study II.Journal of women's health (2002) · 2023Article
- Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases.Biology of sex differences · 2023Review
- Relationship between hysterectomy and stroke in National Health and Nutrition Examination Survey (NHANES) 2007-2018: a cross-sectional study.Annals of translational medicine · 2022Article
- Association between Reproductive Factors and Type 2 Diabetes: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- A prospective study of endometriosis and risk of type 2 diabetes.Diabetologia · 2021Article
- Female reproductive history and risk of type 2 diabetes: A prospective analysis of 126 721 women.Diabetes, obesity & metabolism · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The aim of this study was to determine the associations between hysterectomy, bilateral salpingo-oophorectomy (BSO), and incidence of diabetes in postmenopausal women participating in the Women's Health Initiative (WHI), a series of trials conducted in the United States, during the period 1993-1998. A total of 67,130 postmenopausal women aged 50-79 years were followed for a mean of 13.4 years. Among them, 7,430 cases of diabetes were diagnosed. Multivariable Cox proportional hazards models were used to assess the association between hysterectomy/oophorectomy status and diabetes incidence. Compared with women without hysterectomy, women with hysterectomy had a significantly higher risk of diabetes (hazard ratio = 1.13, 95% confidence interval: 1.06, 1.21). The increased risk of diabetes was similar for women with hysterectomy only and for women with hysterectomy with concomitant BSO. Compared with hysterectomy alone, hysterectomy with BSO was not associated with additional risk of diabetes after stratification by age at hysterectomy and hormone therapy status. In our large, prospective study, we observed that hysterectomy, regardless of oophorectomy status, was associated with increased risk of diabetes among postmenopausal women. However, our data did not support the hypothesis that early loss of ovarian estrogens is a risk factor for type 2 diabetes. The modest increased risk of diabetes associated with hysterectomy may be due to residual confounding, such as the reasons for hysterectomy.
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