Evidence map›Paper›PMID 28339691›Full record

ArticleThe international journal of neuropsychopharmacology2017

Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway.

Feng-Guo Liu, Wen-Feng Hu, Ji-Li Wang, Peng Wang, Yu Gong, Li-Juan Tong, Bo Jiang, Wei Zhang, Yi-Bin Qin, Zhuo Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Alcohol Withdrawal and the Associated Mood Disorders-A Review.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Feng-Guo LiuDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Wen-Feng HuDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Ji-Li WangDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Peng WangDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Yu GongDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Li-Juan TongDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Bo JiangDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Wei ZhangDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Yi-Bin QinDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Zhuo ChenDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Rong-Rong YangDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Chao HuangDepartment of Neurology, Danyang People's Hospital, Danyang, Jiangsu, China (Mr Liu); Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Drs Qin and Yang); Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Tong, Jiang, and Zhang); Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong, Jiangsu, China (Drs Huang, Hu, J.-L. Wang, P. Wang, Gong, Tong, Jiang, and Zhang); Invasive Technology Department, Nantong First People's Hospital, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China (Dr Chen).
Nantong University · CNAffiliated Hospital of Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Z-guggulsterone, an active compound extracted from the gum resin of the tree Commiphora mukul, has been shown to improve animal memory deficits via activating the brain-derived neurotrophic factor signaling pathway. Here, we investigated the antidepressant-like effect of Z-guggulsterone in a chronic unpredictable stress mouse model of depression. Methods: The effects of Z-guggulsterone were assessed in mice with the tail suspension test and forced swimming test. Z-guggulsterone was also investigated in the chronic unpredictable stress model of depression with fluoxetine as the positive control. Changes in hippocampal neurogenesis as well as the brain-derived neurotrophic factor signaling pathway after chronic unpredictable stress/Z-guggulsterone treatment were investigated. The tryptophan hydroxylase inhibitor and the tyrosine kinase B inhibitor were also used to explore the antidepressant-like mechanisms of Z-guggulsterone. Results: Z-guggulsterone (10, 30 mg/kg) administration protected the mice against the chronic unpredictable stress-induced increases in the immobile time in the tail suspension test and forced swimming test and also reversed the reduction in sucrose intake in sucrose preference experiment. Z-guggulsterone (10, 30 mg/kg) administration prevented the reductions in brain-derived neurotrophic factor protein expression levels as well as the phosphorylation levels of cAMP response element binding protein, extracellular signal-regulated kinase 1/2, and protein kinase B in the hippocampus and cortex induced by chronic unpredictable stress. Z-guggulsterone (10, 30 mg/kg) treatment also improved hippocampal neurogenesis in chronic unpredictable stress-treated mice. Blockade of the brain-derived neurotrophic factor signal, but not the monoaminergic system, attenuated the antidepressant-like effects of Z-guggulsterone. Conclusions: Z-guggulsterone exhibits antidepressant activity via activation of the brain-derived neurotrophic factor signaling pathway and upregulation of hippocampal neurogenesis.

Indexed as

AnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDepressive DisorderDisease Models, AnimalDose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesFluoxetineHippocampusMaleMice, Inbred C57BLNeurogenesisPregnenedionesProto-Oncogene Proteins c-aktSignal TransductionAntidepressive AgentsBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinExtracellular Signal-Regulated MAP KinasesFluoxetinepregna-4,17-diene-3,16-dionePregnenedionesProto-Oncogene Proteins c-aktBDNFCREBCUSmajor depressionZ-guggulsterone

Identifiers

PMID28339691
PMCPMC5458345
OpenAlexW2605395876

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.