Evidence map›Paper›PMID 28341860›Full record

ArticleScientific reports2017

High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy.

A M Kivelä, J Huusko, E Gurzeler, A Laine, M H Dijkstra, G Dragneva, C B F Andersen, S K Moestrup, S Ylä-Herttuala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

A M KiveläUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, P.O. Box 1627, FIN-70211, Kuopio, Finland.
J HuuskoUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, P.O. Box 1627, FIN-70211, Kuopio, Finland.
E GurzelerUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, P.O. Box 1627, FIN-70211, Kuopio, Finland.
A LaineUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, P.O. Box 1627, FIN-70211, Kuopio, Finland.
M H DijkstraUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, P.O. Box 1627, FIN-70211, Kuopio, Finland.
G DragnevaUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, P.O. Box 1627, FIN-70211, Kuopio, Finland.
C B F AndersenUniversity of Aarhus, Department of Biomedicine, Ole Worms Allé 3, DK-8000, Aarhus C, Denmark.
S K MoestrupUniversity of Aarhus, Department of Biomedicine, Ole Worms Allé 3, DK-8000, Aarhus C, Denmark.
S Ylä-HerttualaUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, P.O. Box 1627, FIN-70211, Kuopio, Finland. Seppo.Ylaherttuala@uef.fi.
University of Eastern Finland · FIAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could significantly decrease adenoviral transduction efficiency in vivo. Here we demonstrate that mice on a high fat diet have lower transgene expression compared to mice on a regular chow. In addition, on a high fat diet, ApoE

Indexed as

Genetic TherapyGenetic VectorsAdenoviridaeAnimalsApolipoproteins EDiet, High-FatGene Transfer TechniquesLipidsMice, Inbred C57BLMice, Knockout, ApoEReceptors, LDLReceptors, LipoproteinTransgenesVascular Endothelial Growth Factor AApolipoproteins ELipidsReceptors, LDLReceptors, LipoproteinVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouse

Identifiers

PMID28341860
PMCPMC5428218
OpenAlexW2602307827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.