Evidence map›Paper›PMID 28351923›Full record

ArticlemBio2017

Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance.

Céline Loot, Aleksandra Nivina, Jean Cury, José Antonio Escudero, Magaly Ducos-Galand, David Bikard, Eduardo P C Rocha, Didier Mazel

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Céline LootUnité de Plasticité du Génome Bactérien, Institut Pasteur, Paris, France.
Aleksandra NivinaUnité de Plasticité du Génome Bactérien, Institut Pasteur, Paris, France.
Jean CuryCentre National de la Recherche Scientifique UMR 3525, Paris, France.
José Antonio EscuderoUnité de Plasticité du Génome Bactérien, Institut Pasteur, Paris, France.
Magaly Ducos-GalandUnité de Plasticité du Génome Bactérien, Institut Pasteur, Paris, France.
David BikardUnité de Plasticité du Génome Bactérien, Institut Pasteur, Paris, France.
Eduardo P C RochaCentre National de la Recherche Scientifique UMR 3525, Paris, France.
Didier MazelUnité de Plasticité du Génome Bactérien, Institut Pasteur, Paris, France didier.mazel@pasteur.fr.ORCID 0000-0001-6482-6002
Centre National de la Recherche Scientifique · FRDélégation Paris 5 · FR

Funding

European Research Council 281605
6 · The paper itself

Abstract

Integrons ensure a rapid and "on demand" response to environmental stresses driving bacterial adaptation. They are able to capture, store, and reorder functional gene cassettes due to site-specific recombination catalyzed by their integrase. Integrons can be either sedentary and chromosomally located or mobile when they are associated with transposons and plasmids. They are respectively called sedentary chromosomal integrons (SCIs) and mobile integrons (MIs). MIs are key players in the dissemination of antibiotic resistance genes. Here, we used

Indexed as

Adaptation, BiologicalIntegronsRecombination, GeneticBacteriaComputational BiologyEvolution, MolecularInterspersed Repetitive SequencesattC sitescassette dynamicsintegronreplicationsite-specific recombination

Identifiers

PMID28351923
PMCPMC5371416
OpenAlexW2603108228

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.