Trial reportBMC musculoskeletal disorders2017
Sedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity.
Trial report in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Testing a self-determination theory-based process model of physical activity behavior change in rheumatoid arthritis: results of a randomized controlled trial.Translational behavioral medicine · 2021Trial
- Examining the Role of Wearables in Inflammatory Arthritis Care: A Narrative Literature Review.The Journal of rheumatology · 2026Review
- High-intensity exercise for maintained health-enhancing physical activity in patients with rheumatoid arthritis: a randomised controlled trial.BMJ open sport & exercise medicine · 2026Article
- Do publicly funded community physical activity programs for middle-aged and older adults in Ireland work?European journal of ageing · 2025Article
- Twenty-four hour physical activity, sedentary behaviour and sleep profiles in adults living with rheumatoid arthritis: a cross-sectional latent class analysis.Journal of activity, sedentary and sleep behaviors · 2024Article
- Article
- Number of days required to measure sedentary time and physical activity using accelerometery in rheumatoid arthritis: a reliability study.Rheumatology international · 2023Article
- Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training-Rheumatoid Arthritis Trial.ACR open rheumatology · 2023Review
- Increased Prolonged Sitting in Patients with Rheumatoid Arthritis during the COVID-19 Pandemic: A Within-Subjects, Accelerometer-Based Study.International journal of environmental research and public health · 2023Article
- The behavioural epidemiology of sedentary behaviour in inflammatory arthritis: where are we, and where do we need to go?Rheumatology advances in practice · 2023Review
- Comparative analysis of multiorgan toxicity induced by long term use of disease modifying anti-rheumatic drugs.PloS one · 2023Article
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Physical activity in patients with axial spondyloarthritis in a multi-ethnic south-east Asian country.BMC rheumatology · 2021Article
- Changes in Chinese Adults' Physical Activity Behavior and Determinants before and during the COVID-19 Pandemic.Journal of clinical medicine · 2021Article
- Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Isotemporal Substitution of Time Between Sleep and Physical Activity: Associations With Cardiovascular Risk Factors in Early Rheumatoid Arthritis.ACR open rheumatology · 2021Article
- Measurement of sedentary time and physical activity in rheumatoid arthritis: an ActiGraph and activPAL™ validation study.Rheumatology international · 2020Article
- Diurnal patterns of sedentary time in rheumatoid arthritis: associations with cardiovascular disease risk.RMD open · 2020Article
- Characterization of Sedentary Behavior in Heart Failure Patients With Arthritis.Cardiology research · 2020Article
- Theory-informed interventions to promote physical activity and reduce sedentary behaviour in rheumatoid arthritis: a critical review of the literature.Mediterranean journal of rheumatology · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundRheumatoid Arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD). The physical dysfunction symptomatic of RA means people living with this disease spend large periods of the day sedentary, which may further elevate their risk of CVD. The primary aim of this study was to investigate relationships between objectively assessed sedentary behaviour patterns and light physical activity (LPA) with 10-year risk of CVD. Secondary aims were to explore the role of sedentary behaviour patterns and LPA for individual CVD risk factors and functional disability in RA. The extent to which associations were independent of moderate-to-vigorous physical activity (MVPA) engagement was also examined.
methodsBaseline data from a subsample of participants recruited to the Physical Activity in Rheumatoid Arthritis (PARA) study were used to answer current research questions. Sixty-one patients with RA (mean age (± SD) = 54.92 ± 12.39 years) provided a fasted blood sample and underwent physical assessments to evaluate factors associated with their cardiovascular health. Sedentary behaviour patterns (sedentary time, sedentary bouts, sedentary breaks), LPA and MVPA were measured via 7-days of accelerometry. Ten-year CVD risk was computed (Q-risk-score2), and functional disability determined via questionnaire.
resultsRegressions revealed significant positive associations between sedentary time and the number of sedentary bouts per day ≥20 min with 10-year CVD risk, with the reverse true for LPA participation. Associations were independent of MVPA engagement.
conclusionsPromoting LPA participation and restricting sedentary bouts to <20 min may attenuate long-term CVD risk in RA, independent of MVPA engagement.
trial registrationISRCTN04121489 (retrospectively registered 19/10/2012).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.