ArticleGynecologic oncology2017
Frailty measure is more predictive of outcomes after curative therapy for endometrial cancer than traditional risk factors in women 60 and older.
Article in Gynecologic oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04789694 (Prehabilitation in Patients With Gynaecological Cancer Planned for Postponed Surgical Management), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prehabilitation in Patients With Gynaecological Cancer Planned for Postponed Surgical Management: A Prospective Randomised Trial.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of frailty in benign gynecologic surgery: a systematic review.International urogynecology journal · 2021Pooled it
- The role of pre-operative sit-to-stand assessment in robotic hysterectomy surgical outcomes: An observational cohort study.Gynecologic oncology reports · 2026Article
- Interpretable Machine Learning Models for Overall Survival Prediction in Stage I-II Endometrial Cancer Patients Receiving Postoperative Adjuvant Chemotherapy: A SEER-Based Study.International journal of women's health · 2026Article
- [Preoperative frailty and postoperative health outcomes in postmenopausal patients undergoing gynecological cancer surgery: a retrospective observational study].Journal of Korean biological nursing science · 2025Article
- Changes in physical function in older women with endometrial cancer with or without adjuvant therapy.Journal of cancer survivorship : research and practice · 2025Article
- Resilience and frailty among gynecological patients in oncological treatment: the chain mediating role of stigma and health literacy.Frontiers in psychiatry · 2025Article
- Tumor polo-like kinase 4 protein expression reflects lymphovascular invasion, higher Federation of Gynecology and Obstetrics stage, and shortened survival in endometrial cancer patients who undergo surgical resection.BMC women's health · 2024Article
- Characterization and Management of Adverse Reactions in Patients With Advanced Endometrial Cancer Receiving Lenvatinib Plus Pembrolizumab.The oncologist · 2024Article
- Model Predicting the Risk of Endometrial Hyperplasia Developing into Endometrial Cancer.Journal of inflammation research · 2024Article
- Can the Modified Frailty Index (mFI) Predict Intraoperative and Postoperative Complications in Older Women with Endometrial Cancer Undergoing Laparoscopic or Robotic Surgery? A Multicenter Observational Study.Journal of clinical medicine · 2023Article
- Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022). Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer, Geriatric Assessment and Supply Structures.Geburtshilfe und Frauenheilkunde · 2023Article
- Preoperative Prognostic Nutritional Index Is a Prognostic Indicator of Cancer-Specific Survival in Patients Undergoing Endometrial Cancer Surgery.Journal of Korean medical science · 2023Article
- The preoperative G8 geriatric screening tool independently predicts survival in older patients with endometrial cancer: results of a retrospective single-institution cohort study.Journal of cancer research and clinical oncology · 2023Article
- Predictive value of 5-Factor modified frailty index in Oncologic and benign hysterectomies.Gynecologic oncology reports · 2022Article
- Frailty is independently associated with worse outcomes and increased resource utilization following endometrial cancer surgery.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2022Article
- Treatment and outcomes in undifferentiated and dedifferentiated endometrial carcinoma.Journal of gynecologic oncology · 2022Article
- A deficit-accumulation frailty index predicts survival outcomes in patients with gynecologic malignancy.Gynecologic oncology · 2021Article
- An artificial immune system with bootstrap sampling for the diagnosis of recurrent endometrial cancers.Open medicine (Warsaw, Poland) · 2021Article
- Treatment of Rectal Cancer in Older Adults.Current oncology reports · 2018Review
- Attention to bone health in follow-up of gynaecological cancers in tertiary care.Women's health (London, England)Observational
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectivesTo determine if readily obtainable markers of frailty predict disease-free survival (DFS) in elderly women with endometrial cancer treated with curative intent.
methods88 consecutive women≥age 60 treated with surgery, chemotherapy and radiation for stage I-IV endometrial cancer were included. We considered the following health deficits as markers of "frailty": albumin <3.5mg/dL, hemoglobin <10mg/dL, BMI<20kg/m,
resultsThe median age was 68.5 (range 60-88years). The majority of women (65/88) had at least one frailty factor at baseline and 23/88 had two or more. All women received radiation and chemotherapy. Treatment was delayed, modified or truncated in 46% (40/88) of women due to treatment-related toxicity. Age (< 70 vs. ≥70 y) did not independently predict toxicity or recurrence risk. Women with at least one baseline frailty factor had twice the risk of disease recurrence (HR=2.21;95% CI:1.02-4.80) when adjusted for age, stage, grade and Charlson score. The 3-year DFS was 77% in those with no frailty markers and 48% in those with at least one (p=0.02). The presence of a frailty marker also predicted shortened overall survival (HR=2.34;95% CI:1.08-5.03) irrespective of treatment administered and stage of disease.
conclusionsA combined frailty measure was a more robust predictor of DFS and OS than patient age, tumor characteristics and comorbidities in this cohort of older women with very good functional status.
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