Evidence map›Paper›PMID 28373285›Full record

ArticleThe Journal of biological chemistry2017

Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester.

Baiba K Gillard, G Randall Bassett, Antonio M Gotto, Corina Rosales, Henry J Pownall

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. HDL Receptor inFrontiers in cell and developmental biology · 2022
    Review
  3. High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1Arteriosclerosis, thrombosis, and vascular biology · 2021
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Acteoside FromFrontiers in pharmacology · 2019
    Article
  11. Article
  12. Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Article
  13. Article
  14. Article
  15. Article
  16. Cholesterol: Can't Live With It, Can't Live Without It.Methodist DeBakey cardiovascular journal
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Baiba K GillardFrom the Houston Methodist Research Institute, Houston Texas 77030, bgillard@houstonmethodist.org.ORCID 0000-0002-2527-5102
G Randall Bassettthe Baylor College of Medicine, Houston, Texas 77030.
Antonio M GottoFrom the Houston Methodist Research Institute, Houston Texas 77030.
Corina RosalesFrom the Houston Methodist Research Institute, Houston Texas 77030.
Henry J PownallFrom the Houston Methodist Research Institute, Houston Texas 77030.
Houston Methodist · USBaylor College of Medicine · US

Funding

Therapeutic Approaches to Dysregulated HDL MetabolismR01HL056865 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI POWNALL, HENRY J. · 1997 to 2015
$5.2M
High Density Lipoprotein Biogenesis and SpeciationR01HL129767 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI POWNALL, HENRY J., ROSALES, CORINA · 2016 to 2019
$2.3M
NHLBI NIH HHS R01 HL056865NHLBI NIH HHS R01 HL129767
6 · The paper itself

Abstract

Reverse cholesterol transport (transfer of macrophage-cholesterol in the subendothelial space of the arterial wall to the liver) is terminated by selective high density lipoprotein (HDL)-cholesteryl ester (CE) uptake, mediated by scavenger receptor class B, type 1 (SR-B1). We tested the validity of two models for this process: "gobbling,"

Indexed as

AnimalsApolipoprotein A-IApolipoprotein A-IICHO CellsCholesterol EstersCricetinaeCricetulusHepatocytesHumansLipoproteins, HDLScavenger Receptors, Class BApolipoprotein A-IApolipoprotein A-IICholesterol EstersHDL cholesteryl esterLipoproteins, HDLSCARB1 protein, humanScavenger Receptors, Class Bapolipoproteinapolipoprotein AIIatherosclerosischolesterolhigh-density lipoprotein (HDL)lipidreverse cholesterol transportscavenger receptorscavenger receptor B1selective lipid uptake

Identifiers

PMID28373285
PMCPMC5448121
OpenAlexW2604980247

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.