ArticleScientific reports2017
The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
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- Coral Genetic Structure in the Western Indian Ocean Mirrors Ocean Circulation and Thermal Stress History.Evolutionary applications · 2026Article
- Coral thermotolerance retained following year-long exposure to a novel environment.Science advances · 2025Article
- Genome-wide analysis to uncover how Pocillopora acuta survives the challenging intertidal environment.Scientific reports · 2024Article
- Phenotypic plasticity for improved light harvesting, in tandem with methylome repatterning in reef-building corals.Molecular ecology · 2024Article
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- Ginsenoside protopanaxadiol protects adult retinal pigment epithelial-19 cells from chloroquine by modulating autophagy and apoptosis.PloS one · 2022Article
- Review
- Seascape genomics reveals candidate molecular targets of heat stress adaptation in three coral species.Molecular ecology · 2021Article
- Selenium Nanoparticles by Moderating Oxidative Stress Promote Differentiation of Mesenchymal Stem Cells to Osteoblasts.International journal of nanomedicine · 2021Article
- Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Seascape genomics as a new tool to empower coral reef conservation strategies: An example on north-western PacificEvolutionary applications · 2020Article
- Biological rhythms in the deep-sea hydrothermal mussel Bathymodiolus azoricus.Nature communications · 2020Article
- The Unique Antimicrobial Recognition and Signaling Pathways in Tardigrades with a Comparison Across Ecdysozoa.G3 (Bethesda, Md.) · 2020Article
- Comparative analysis of the Pocillopora damicornis genome highlights role of immune system in coral evolution.Scientific reports · 2018Article
- Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coralF1000Research · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coral reefs are of major ecological and socio-economic interest. They are threatened by global warming and natural pressures such as solar ultraviolet radiation. While great efforts have been made to understand the physiological response of corals to these stresses, the signalling pathways involved in the immediate cellular response exhibited by corals remain largely unknown. Here, we demonstrate that c-Jun N-terminal kinase (JNK) activation is involved in the early response of corals to thermal and UV stress. Furthermore, we found that JNK activity is required to repress stress-induced reactive oxygen species (ROS) accumulation in both the coral Stylophora pistillata and human skin cells. We also show that inhibiting JNK activation under stress conditions leads to ROS accumulation, subsequent coral bleaching and cell death. Taken together, our results suggest that an ancestral response, involving the JNK pathway, is remarkably conserved from corals to human, protecting cells from the adverse environmental effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.