Evidence map›Paper›PMID 28375000›Full record

ReviewChemical reviews2017

Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Abraham J Waldman, Tai L Ng, Peng Wang, Emily P Balskus

Abstract readReview
In one paragraph

Review in Chemical reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Review
  3. Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Sustainable electrochemical synthesis of aliphatic nitro-Beilstein journal of organic chemistry · 2025
    Article
  12. Article
  13. Heterocycles in Medicinal Chemistry II.Molecules (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Elucidation of Chalkophomycin Biosynthesis RevealsJournal of the American Chemical Society · 2024
    Article
  16. Elucidation of chalkophomycin biosynthesis revealsbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abraham J WaldmanDepartment of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.
Tai L NgDepartment of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.
Peng WangDepartment of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.ORCID http://orcid.org/0000-0001-5985-5714

Funding

Principles of Scientific Citizenship: Ethics, Communication, and Leadership for ScientistsT32GM095450 · NIGMS · HARVARD UNIVERSITY · PI WALKER, SUZANNE · 2011 to 2020
$3.5M
Biocompatible Chemistry for In Vivo Metabolite ModificationDP2GM105434 · NIGMS · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2012 to 2012
$2.5M
NIGMS NIH HHS DP2 GM105434NIGMS NIH HHS T32 GM095450
6 · The paper itself

Abstract

Natural products that contain functional groups with heteroatom-heteroatom linkages (X-X, where X = N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and diversity of these structural motifs has captured the interest of synthetic and biological chemists alike. Functional groups containing X-X bonds are found in all major classes of natural products and often impart significant biological activity. This review presents our current understanding of the biosynthetic logic and enzymatic chemistry involved in the construction of X-X bond containing functional groups within natural products. Elucidating and characterizing biosynthetic pathways that generate X-X bonds could both provide tools for biocatalysis and synthetic biology, as well as guide efforts to uncover new natural products containing these structural features.

Indexed as

Biological ProductsEnzymesNitric OxideBiological ProductsEnzymesNitric Oxide

Identifiers

PMID28375000
PMCPMC5534343

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.