Evidence map›Paper›PMID 28375205›Full record

Trial reportTranslational psychiatry2017

Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects.

F Mueller, C Lenz, P C Dolder, S Harder, Y Schmid, U E Lang, M E Liechti, S Borgwardt

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02308969 (Neuronal Correlates of Altered States of Consciousness), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02308969 early_phase1completednot on this map

Neuronal Correlates of Altered States of Consciousness

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2014 to 2015Enrolled24ConditionsHealthyArmsLSD, Placebo
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  7. Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020
    Trial
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  11. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

F MuellerDepartment of Psychiatry, Universitäre Psychiatrische Kliniken, University of Basel, Basel, Switzerland.
C LenzDepartment of Psychiatry, Universitäre Psychiatrische Kliniken, University of Basel, Basel, Switzerland.
P C DolderDivision of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
S HarderDivision of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
Y SchmidDivision of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
U E LangDepartment of Psychiatry, Universitäre Psychiatrische Kliniken, University of Basel, Basel, Switzerland.
M E LiechtiDivision of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
S BorgwardtDepartment of Psychiatry, Universitäre Psychiatrische Kliniken, University of Basel, Basel, Switzerland.
University Hospital of Basel · CHUniversitäre Psychiatrische Kliniken Basel · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysergic acid diethylamide (LSD) induces profound changes in various mental domains, including perception, self-awareness and emotions. We used functional magnetic resonance imaging (fMRI) to investigate the acute effects of LSD on the neural substrate of emotional processing in humans. Using a double-blind, randomised, cross-over study design, placebo or 100 μg LSD were orally administered to 20 healthy subjects before the fMRI scan, taking into account the subjective and pharmacological peak effects of LSD. The plasma levels of LSD were determined immediately before and after the scan. The study (including the a priori-defined study end point) was registered at ClinicalTrials.gov before study start (NCT02308969). The administration of LSD reduced reactivity of the left amygdala and the right medial prefrontal cortex relative to placebo during the presentation of fearful faces (P<0.05, family-wise error). Notably, there was a significant negative correlation between LSD-induced amygdala response to fearful stimuli and the LSD-induced subjective drug effects (P<0.05). These data suggest that acute administration of LSD modulates the engagement of brain regions that mediate emotional processing.

Indexed as

AdultAmygdalaAwarenessBrainCross-Over StudiesDouble-Blind MethodEmotionsFearFemaleHallucinogensHealthy VolunteersHumansLysergic Acid DiethylamideMagnetic Resonance ImagingMaleMiddle AgedHallucinogensLysergic Acid Diethylamide

Identifiers

PMID28375205
PMCPMC5416695
OpenAlexW2604586582

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.