Evidence map›Paper›PMID 28396569›Full record

ArticleJournal of the American Heart Association2017

Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study.

Aditi Shendre, Marguerite R Irvin, Howard Wiener, Degui Zhi, Nita A Limdi, Edgar T Overton, Sadeep Shrestha

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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  10. Sphingolipid Metabolism and Signaling in Endothelial Cell Functions.Advances in experimental medicine and biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aditi ShendreDepartment of Epidemiology, University of Alabama at Birmingham, AL.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, AL.
Howard WienerDepartment of Epidemiology, University of Alabama at Birmingham, AL.
Degui ZhiDepartment of Biostatistics, University of Alabama at Birmingham, AL.
Nita A LimdiDepartment of Neurology, University of Alabama at Birmingham, AL.
Edgar T OvertonDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, AL.
Sadeep ShresthaDepartment of Epidemiology, University of Alabama at Birmingham, AL sshrestha@uab.edu.
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
GWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6M
Patient Oriented Research in Personalized Antithrombotic TherapyK24HL133373 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2016 to 2025
$1.2M
Genetic Variants in Calcium Channel and Binding Proteins Underlying cIMT in HIVR56HL125061 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHRESTHA, SADEEP · 2015 to 2015
$761k
NHGRI NIH HHS U01 HG004402NHLBI NIH HHS K24 HL133373NHLBI NIH HHS R56 HL125061NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

backgroundLocal ancestry in relation to clinical cardiovascular events (CVEs) among African Americans can provide insight into their genetic susceptibility to the disease. METHODS AND

resultsWe examined local European ancestry (LEA) association with CVEs among 3000 African Americans from the Atherosclerosis Risk in Communities Study (ARIC). We estimated LEA using

conclusionsFuture studies are needed to replicate and/or determine the causal variants driving our associations and explore clinical applications for those consistently associated with CVEs.

Indexed as

Genetic LociPolymorphism, Single NucleotideAtherosclerosisBlack or African AmericanCardiovascular DiseasesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHeredityHumansLinkage DisequilibriumLogistic ModelsMaleMiddle AgedOdds RatioPedigreeadmixture mappingassociation studiescardiovascular eventsgenetic epidemiologygeneticsgenome‐wide association scanrace and ethnicity

Identifiers

PMID28396569
PMCPMC5532995
OpenAlexW2606198827

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.