Evidence map›Paper›PMID 28399396›Full record

ReviewDevelopmental cell2017

Crosstalk between the Secretory and Autophagy Pathways Regulates Autophagosome Formation.

Saralin Davis, Juan Wang, Susan Ferro-Novick

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05101694 (Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS), which is not on this map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05101694 unknown statusnot on this mapstarted 2022, after this paper: background citation

Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS

Typeobservational_patient_registrySponsorSoutheast University, ChinaRan2022 to 2023Enrolled60ConditionsARDS
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
  2. Article
  3. Extracellular vesicles inEXO : beyond the cell · 2026
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Saralin DavisDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0668, USA.
Juan WangDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0668, USA.
Susan Ferro-NovickDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0668, USA. Electronic address: sfnovick@ucsd.edu.
University of California, San Diego · US

Funding

The role of a CK1 kinase in membrane trafficR01GM114111 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FERRO-NOVICK, SUSAN · 2015 to 2018
$1.5M
The contribution of the secretory pathway to macroautophagyR01GM115422 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FERRO-NOVICK, SUSAN · 2016 to 2018
$1.1M
NIGMS NIH HHS R01 GM114111NIGMS NIH HHS R01 GM115422
6 · The paper itself

Abstract

The induction of autophagy by nutrient deprivation leads to a rapid increase in the formation of autophagosomes, unique organelles that replenish the cellular pool of nutrients by sequestering cytoplasmic material for degradation. The urgent need for membranes to form autophagosomes during starvation to maintain homeostasis leads to a dramatic rearrangement of intracellular membranes. Here we discuss recent findings that have begun to uncover how different parts of the secretory pathway directly and indirectly contribute to autophagosome formation during starvation.

Indexed as

AutophagySecretory PathwayAnimalsAutophagosomesEndoplasmic ReticulumHumansMitochondriaModels, Biologicalautophagosome formationautophagysecretory pathway

Identifiers

PMID28399396
PMCPMC5493037
OpenAlexW2606085862

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.