Evidence map›Paper›PMID 28402388›Full record

ArticleAmerican journal of hypertension2017

Cognitive Associates of Current and More Intensive Control of Hypertension: Findings From the Hispanic Community Health Study/Study of Latinos.

Melissa Lamar, Donghong Wu, Ramon A Durazo-Arvizu, Adam M Brickman, Hector M Gonzalez, Wassim Tarraf, Martha L Daviglus

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Melissa LamarDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Donghong WuInstitute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA.
Ramon A Durazo-ArvizuInstitute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
Hector M GonzalezDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA.
Wassim TarrafInstitute of Gerontology, Wayne State University, Detroit, Michigan, USA.
Martha L DaviglusDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
University of Illinois Chicago · USColumbia University · USMichigan State University · US

Funding

Study of Latinos Investigation of Neurocognitive Aging 2R56AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2020 to 2021
$8.7M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
The role of myelin & vascular risk on brain structure and function in agingK01AG040192 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAMAR, MELISSA · 2012 to 2015
$522k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIA NIH HHS K01 AG040192NIA NIH HHS R01 AG048642NIA NIH HHS R56 AG048642
6 · The paper itself

Abstract

backgroundHypertension control in Hispanics/Latinos lag behind general US trends by 10-15%. Intensive systolic blood pressure (SBP) management <120 mm Hg may significantly reduce morbidity/mortality risk in adults with hypertension; less is known about cognition. We investigated cross-sectional associations of cognition with observed hypertension control at currently recommended (SBP < 140 mm Hg) and more intensive (SBP < 120 mm Hg) levels using baseline data from the Hispanic Community Health Study/Study of Latinos.

methodsFrom this multicenter cohort study, we focused on 1,735 Hispanic/Latino men and women ages 45-74 years with hypertension and verified antihypertensive use. Verbal fluency, information processing speed, learning, and memory were tested in Spanish or English.

resultsSeparate linear regressions revealed that being on 1 vs. >1 antihypertensive medication was not associated with cognition; however, individuals with SBP controlled to currently recommended levels outperformed individuals with uncontrolled SBP on verbal fluency [Beta = 1.44 (0.52), P < 0.01] and information processing speed [Beta = 3.01 (0.89), P < 0.001] in age-adjusted regression analyses; only information processing speed remained significant (P < 0.05) after additional adjustments including acculturation, health insurance, and other cardiovascular disease risk factors. When regrouping individuals based on more intensive SBP control, individuals with levels <120 mm Hg outperformed individuals with higher SBP on verbal fluency regardless of adjustments (P < 0.01). More intensive rather than currently recommended levels of control associated with higher verbal fluency performance regardless of adjustments (P < 0.05).

conclusionsIndividual cognitive test scores related to distinct SBP management with more intensive management appearing more robust against confounders. While cognitive associations with hypertension in Hispanics/Latinos may be multifactorial, different levels of SBP control should be considered in future prospective intervention studies.

Indexed as

CognitionAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesExecutive FunctionFemaleHealth Knowledge, Attitudes, PracticeHispanic or LatinoHumansHypertensionLinear ModelsMaleMiddle AgedMultivariate AnalysisProspective StudiesAntihypertensive Agentsantihypertensive treatmentblood pressureblood pressure controlcognitionHCHS/SOLHispanics/Latinos.hypertension

Identifiers

PMID28402388
PMCPMC5861562
OpenAlexW2605997387

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.