ArticleJCI insight2017
The impact of environmental enrichment on the murine inflammatory immune response.
Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cytokines and Immune Cells Profile in Different Tissues of Rodents Induced by Environmental Enrichment: Systematic Review.International journal of molecular sciences · 2022Pooled it
- Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis.BMC biology · 2022Pooled it
- Experimental robustness and reproducibility of the murine cecal ligation and puncture sepsis model.Intensive care medicine experimental · 2026Article
- Lipid-Based Nanocarriers for Curcumin Delivery: A Promising Strategy in The Management of Inflammatory Diseases.International journal of nanomedicine · 2026Review
- Neuroimmune modulatory effects of the NLRP3 inflammasome: the role of sex and living environment in brain affecting conditions.Frontiers in immunology · 2025Review
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Immune transcriptomic profile in adult female pigs: dominance status has more influence than environmental enrichment.BMC genomics · 2024Article
- Exploring the similarities between risk factors triggering depression in humans and elevated in-cage "inactive but awake" behavior in laboratory mice.Frontiers in veterinary science · 2024Article
- Environmental eustress improves postinfarction cardiac repair via enhancing cardiac macrophage survival.Science advances · 2022Article
- Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview.Animals : an open access journal from MDPI · 2022Review
- Animal Welfare and Resistance to Disease: Interaction of Affective States and the Immune System.Frontiers in veterinary science · 2022Article
- Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice.Nature communications · 2021Article
- Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- An Enriched Environment Alters DNA Repair and Inflammatory Responses After Radiation Exposure.Frontiers in immunology · 2021Article
- Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice.Frontiers in immunology · 2021Review
- The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection.Hippocampus · 2019Article
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- Article
- Environmental Enrichment Increases Radiation-induced Apoptosis Not Spontaneous Apoptosis in Mouse Intestinal Crypt Cells.In vivo (Athens, Greece)Article
- Barrier-environment interactions along the gut-brain axis and their influence on cognition and behaviour throughout the lifespan.Journal of psychiatry & neuroscience : JPNReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living in a mentally and physically stimulating environment has been suggested to have a beneficial effect on the immune response. This study investigates these effects, utilizing a 2-week program of environmental enrichment (EE) and 2 models of acute inflammation: zymosan-induced peritonitis (ZIP) and the cecal ligation and puncture (CLP) model of sepsis. Our results revealed that following exposure to EE, mice possessed a significantly higher circulating neutrophil to lymphocyte ratio compared with control animals. When subject to ZIP, EE animals exhibit enhanced neutrophil and macrophage influx into their peritoneal cavity. Corresponding results were found in CLP, where we observed an improved capacity for enriched animals to clear systemic microbial infection. Ex vivo investigation of leukocyte activity also revealed that macrophages from EE mice presented an enhanced phagocytic capacity. Supporting these findings, microarray analysis of EE animals revealed the increased expression of immunomodulatory genes associated with a heightened and immunoprotective status. Taken together, these results provide potentially novel mechanisms by which EE influences the development and dynamics of the immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.