Metformin and cancer in type 2 diabetes: a systematic review and comprehensive bias evaluation.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
   Trial
2. Advances in Anti-Cancer Drug Development: Metformin as Anti-Angiogenic Supplemental Treatment for Glioblastoma.International journal of molecular sciences · 2024
   Review
3. Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus.Journal of breast cancer · 2024
   Article
4. Metformin use and long-term risk of benign prostatic hyperplasia: a population-based cohort study.BMJ open · 2020
   Article
5. The Diagnostic and Therapeutic Role of Leptin and Its Receptor ObR in Glioblastoma Multiforme.Cancers · 2020
   Review
6. Outcomes after surgery in patients with diabetes who used metformin: a retrospective cohort study based on a real-world database.BMJ open diabetes research & care · 2020
   Article
7. Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank.BMJ open diabetes research & care · 2020
   Article
8. Metformin as Potential Therapy for High-Grade Glioma.Cancers · 2020
   Article
9. Effect of metformin on cell proliferation, apoptosis, migration and invasion in A172 glioma cells and its mechanisms.Molecular medicine reports · 2019
   Article
10. Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.Cell reports · 2018
    Article
11. Promises and pitfalls of electronic health record analysis.Diabetologia · 2018
    Review
12. Differences in risk factors of malignancy between men and women with type 2 diabetes: A retrospective case-control study.Oncotarget · 2017
    Article

Corrections and comments

• Erratum for
  Metformin and cancer in type 2 diabetes: a systematic review and comprehensive bias evaluation.2017

Authors and funding

7 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.