ArticlePloS one2017
Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: Results from Taiwan Stroke Registry.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A Low LDL-C Level but not Statin Use is Associated with In-hospital Mortality in Spontaneous Intracerebral Hemorrhage; The J-ICH Registry.Journal of atherosclerosis and thrombosis · 2026Article
- Association Between High-Density Lipoprotein-to-Low-Density Lipoprotein Ratio and Clinical Outcomes in Intracerebral Hemorrhage: Results From a Multicenter Prospective Registry.Journal of the American Heart Association · 2026Article
- Genetic and measured LDL-C: Differential and interactive effects on cardiovascular and stroke subtypes.American journal of preventive cardiology · 2025Article
- Low-density lipoprotein cholesterol and severity of intracerebral hemorrhage: Insights from the SIREN study.Journal of the neurological sciences · 2025Article
- Predictors of poor outcomes in patients with intracerebral hemorrhage.Frontiers in neurology · 2025Article
- Impact of LDL-C levels on severity and outcome of intracranial haemorrhage: a single-centre retrospective study.BMJ neurology open · 2025Article
- The impact of antiplatelet drugs on recurrent stroke in patients with intracerebral hemorrhage.Heliyon · 2023Article
- Statins and 90-Day Functional Performance and Survival in Patients with Spontaneous Intracerebral Hemorrhage.Journal of clinical medicine · 2023Article
- Characterization of a mutantFrontiers in immunology · 2023Article
- Clinical and paraclinical predictors of early neurological deterioration and poor outcome in spontaneous intracerebral hemorrhage.The Egyptian journal of neurology, psychiatry and neurosurgery · 2023Article
- Predictive value of the apolipoprotein B/A1 ratio in intracerebral hemorrhage outcomes.Journal of clinical laboratory analysis · 2022Article
- Atrial Fibrillation in Spontaneous Intracerebral Hemorrhage, Dijon Stroke Registry (2006-2017).Journal of the American Heart Association · 2021Article
- Associations between low-density lipoprotein cholesterol and haemorrhagic stroke.Journal of geriatric cardiology : JGC · 2021Article
- Revisiting promising preclinical intracerebral hemorrhage studies to highlight repurposable drugs for translation.International journal of stroke : official journal of the International Stroke Society · 2021Article
- Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women.Frontiers in neurology · 2021Article
- Low-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan.Frontiers in neurology · 2021Article
- The predictive role of the neutrophil-lymphocyte ratio in the prognosis of adult patients with stroke.Chinese neurosurgical journal · 2020Review
- Nontraumatic spontaneous intracerebral hemorrhage: Baseline characteristics and early outcomes.Brain and behavior · 2020Article
- Lipid Paradox in Statin-Naïve Acute Ischemic Stroke But Not Hemorrhagic Stroke.Frontiers in neurology · 2018Article
- Prognostic role of neutrophil lymphocyte ratio in patients with spontaneous intracerebral hemorrhage.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
24 authors at 17 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low cholesterol levels may have association with intracerebral hemorrhage (ICH) severity at admission and 3-month outcomes. This study used data obtained from a multi-center stroke registry program in Taiwan. We categorized acute spontaneous ICH patients, based on their baseline levels of total cholesterol (TC) measured at admission, into 3 groups with <160, 160-200 and >200 mg/dL of TC. We evaluated risk of having initial stroke severity, with National Institutes of Health Stroke Scale (NIHSS) >15 and unfavorable outcomes (modified Rankin Scale [mRS] score >2, 3-month mortality) after ICH by the TC group. A total of 2444 ICH patients (mean age 62.5±14.2 years; 64.2% men) were included in this study and 854 (34.9%) of them had baseline TC <160 mg/dL. Patients with TC <160 mg/dL presented more often severe neurological deficit (NIHSS >15), with an adjusted odds ratio [aOR] of 1.80; 95% confidence interval [CI], 1.41-2.30), and 3-month mRS >2 (aOR, 1.41; 95% CI, 1.11-1.78) using patients with TC >200 mg/dL as reference. Those with TC >160 mg/dL and body mass index (BMI) <22 kg/m2 had higher risk of 3-month mortality (aOR 3.94, 95% CI 1.76-8.80). Prior use of lipid-lowering drugs (2.8% of the ICH population) was not associated with initial severity and 3-month outcomes. A total cholesterol level lower than 160 mg/dL was common in patients with acute ICH and was associated with greater neurological severity on presentation and poor 3-month outcomes, especially with lower BMI.
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