ArticleImmunity2017
Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells.
Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors.Signal transduction and targeted therapy · 2026Article
- Analysis of peripheral blood T-cell levels for predicting immunotherapy response sensitivity in squamous cell carcinoma of the head and neck.Frontiers in molecular biosciences · 2026Article
- Transcriptomic signatures associated with autoimmune thyroiditis in papillary thyroid carcinoma and cancer immunotherapy-induced thyroid dysfunction.Computational and structural biotechnology journal · 2022Article
- Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity.Journal of cellular immunology · 2021Article
- Tumor necrosis family receptor superfamily member 9/tumor necrosis factor receptor-associated factor 1 pathway on hepatitis C viral persistence and natural history.World journal of hepatology · 2020Review
- Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells.BMC research notes · 2020Article
- Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report.Frontiers in pharmacology · 2020Article
- GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response.Frontiers in immunology · 2020Review
- An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.The Journal of clinical investigation · 2018Article
- Checks and Balances in Autoimmune Vasculitis.Frontiers in immunology · 2018Review
- Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer.OncoTargets and therapy · 2018Review
- Biomarkers for Immune Checkpoint Inhibitors in Melanoma.Frontiers in oncology · 2018Review
- CD28 family of receptors inter-connect in the regulation of T-cells.Receptors & clinical investigation · 2017Article
- Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8Frontiers in immunology · 2017Article
- H3K4me3 mediates the NF-κB p50 homodimer binding to theOncoimmunologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identity of PD-1 dependency on other receptors and signaling has been unclear. In a recent issue of Science, Hui et al. (2017) and Kamphorst et al. (2017) now show that CD28 expression is a target of PD-1-associated phosphatases and is needed for T cell expansion in anti-PD-1 immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.