Evidence map›Paper›PMID 28424242›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.

Olesya Chornoguz, Robert S Hagan, Azeb Haile, Matthew L Arwood, Christopher J Gamper, Arnob Banerjee, Jonathan D Powell

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Regulation of CD8Cellular & molecular immunology · 2023
    Review
  9. The African-centric P47S Variant ofCancer research communications · 2023
    Article
  10. Article
  11. Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  12. Glutaminolysis and peripheral CD4Frontiers in immunology · 2023
    Review
  13. Identifying Phenotypically Distinct Fibroblast Subsets in Type 2 Diabetes-Associated Iatrogenic Laryngotracheal Stenosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2022
    Article
  14. Review
  15. Review
  16. Control of CD4Current topics in microbiology and immunology · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Olesya ChornoguzDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Robert S HaganDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-1504-0086
Azeb HaileDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Matthew L ArwoodDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Christopher J GamperDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0003-0253-2177
Arnob BanerjeeProgram in Oncology, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201; and.
Jonathan D PowellDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287; poweljo@jhmi.edu.
Bloomberg (United States) · USUniversity of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · US

Funding

A central role for mTOR in Determining T Cell Activation versus ToleranceR01AI077610 · NIAID · JOHNS HOPKINS UNIVERSITY · PI POWELL, JONATHAN D · 2009 to 2019
$4.0M
Transplantation tolerance and immune function following mTOR inhibition.R01AI091481 · NIAID · JOHNS HOPKINS UNIVERSITY · PI POWELL, JONATHAN D · 2010 to 2013
$1.6M
Transcriptional regulation of CD8+ T cell differentiationK08HL093027 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BANERJEE, ARNOB · 2010 to 2014
$658k
NHLBI NIH HHS K08 HL093027NIAID NIH HHS R01 AI077610NIAID NIH HHS R01 AI091481
6 · The paper itself

Abstract

CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesCell DifferentiationChromatin Assembly and DisassemblyGene Expression RegulationInterferon-gammaMass SpectrometryMechanistic Target of Rapamycin Complex 1MiceMultiprotein ComplexesMutationPhosphorylationProteomicsSirolimusT-bet Transcription FactorT-Box Domain ProteinsInterferon-gammaMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesSirolimusT-bet Transcription FactorT-Box Domain ProteinsTOR Serine-Threonine Kinases

Identifiers

PMID28424242
PMCPMC5458608
OpenAlexW2608274564

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.