Evidence map›Paper›PMID 28435246›Full record

ArticleInternational journal of nanomedicine2017

Cuprous oxide nanoparticle-inhibited melanoma progress by targeting melanoma stem cells.

Bin Yu, Ye Wang, Xinlu Yu, Hongxia Zhang, Ji Zhu, Chen Wang, Fei Chen, Changcheng Liu, Jingqiang Wang, Haiying Zhu

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Metal-based nanoparticle in cancer treatment: lessons learned and challenges.Frontiers in bioengineering and biotechnology · 2024
    Review
  2. Article
  3. Article
  4. Review
  5. Melanoma treatment: from conventional to nanotechnology.Journal of cancer research and clinical oncology · 2018
    Review
  6. Article
  7. Article
  8. Article
  9. Metallic Nanoparticles for Cancer Immunotherapy.Materials today (Kidlington, England)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bin YuDepartment of Cell Biology, Second Military Medical University.
Ye WangDepartment of Urinary Surgery.
Xinlu YuDepartment of Cell Biology, Second Military Medical University.
Hongxia ZhangDepartment of Cell Biology, Second Military Medical University.
Ji ZhuDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Chen WangDepartment of Cell Biology, Second Military Medical University.
Fei ChenDepartment of Cell Biology, Second Military Medical University.
Changcheng LiuDepartment of Cell Biology, Second Military Medical University.
Jingqiang WangState Key Laboratory of Genetic Engineering and Collaborative Innovation Center of Genetics and Development, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Genetics and Development, School of Life Sciences, Fudan University.
Haiying ZhuDepartment of Cell Biology, Second Military Medical University.
Second Military Medical University · CNState Key Laboratory of Genetic Engineering

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have shown that metal and metal oxide have a potential function in antitumor therapy. Our previous studies demonstrated that cuprous oxide nanoparticles (CONPs) not only selectively induce apoptosis of tumor cells in vitro but also inhibit the growth and metastasis of melanoma by targeting mitochondria with little hepatic and renal toxicities in mice. As a further study, our current research revealed that CONPs induced apoptosis of human melanoma stem cells (CD271

Indexed as

AnimalsAntineoplastic AgentsApoptosisCell Line, TumorCell SurvivalCopperHumansMelanomaMiceMice, Inbred NODMice, SCIDMitochondriaNanoparticlesNeoplastic Stem CellsNerve Tissue ProteinsReceptors, Nerve Growth FactorAntineoplastic AgentsCoppercuprous oxideNerve Tissue ProteinsNGFR protein, humanReceptors, Nerve Growth FactorA375 cell linecancer stem cellsclathrin-mediated endo cytosisCONPscuprous oxide nanoparticlesmelanomaMITFSOX10WM266-4 cell line

Identifiers

PMID28435246
PMCPMC5388199
OpenAlexW2604737609

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.