Evidence map›Paper›PMID 28436151›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2017

Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population.

Qian Peng, Nicholas J Schork, Kirk C Wilhelmsen, Cindy L Ehlers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qian PengDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California.
Nicholas J SchorkDepartment of Human Biology, J. Craig Venter Institute, La Jolla, California.
Kirk C WilhelmsenDepartment of Genetics and Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID http://orcid.org/0000-0002-4432-8302
Cindy L EhlersDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California.

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI Thomas Girke, NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
Deep sequencing studies for cannabis and stimulant dependenceR01DA030976 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EHLERS, CINDY L, GELERNTER, JOEL · 2010 to 2014
$16.5M
RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANSR37AA010201 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI EHLERS, CINDY L · 2007 to 2015
$7.0M
Genome Wide Association of Coronary Artery Disease and Related Risk FactorsR01HL089655 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BROECKEL, ULRICH · 2008 to 2012
$3.8M
Genomic Predictors of Combat Stress Vulnerability and ResilienceR01MH093500 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M · 2011 to 2013
$2.7M
The Bipolar Genome StudyR01MH094483 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CRAIG, DAVID W, EDENBERG, HOWARD J · 2012 to 2014
$2.2M
Big data analytics for the evaluation of whole genome sequence and transcriptome data in alcohol researchK25AA025095 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI PENG, QIAN · 2016 to 2020
$807k
Allele-specific Mapping in Alzheimer's DiseaseR01AG035020 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, TYCKO, BENJAMIN · 2010 to 2014
$592k
NHLBI NIH HHS R01 HL089655NIAAA NIH HHS K25 AA025095NIAAA NIH HHS R37 AA010201NIA NIH HHS R01 AG035020NIA NIH HHS U19 AG023122NIDA NIH HHS R01 DA030976NIMH NIH HHS R01 MH093500NIMH NIH HHS R01 MH094483
6 · The paper itself

Abstract

EEG alpha activity is the dominant oscillation in most adult humans, is highly heritable, and has been associated with a number of cognitive functions. Two EEG phenotypes, low- and high-voltage alpha (LVA & HVA), have been demonstrated to have high heritabilities. They have different prevalence depending on a population's ancestral origins. In the present study we assessed the influence of ancestry admixture on EEG alpha power, and conducted a whole genome sequencing association analysis and an ancestry-informed polygenic study on those phenotypes in a Native American (NA) population that has a high prevalence of LVA. Seven common variants, in LD with each other upstream from gene ASIC2, reached genome-wide significance (p = 2 × 10

Indexed as

ElectroencephalographyGenome-Wide Association StudyPolymorphism, Single NucleotideAcid Sensing Ion ChannelsAdolescentAdultAgedAged, 80 and overAlpha RhythmBiomarkersFemaleGene FrequencyGenetics, PopulationHumansIndians, North AmericanMaleAcid Sensing Ion ChannelsASIC2 protein, humanBiomarkersT-Cell Intracellular Antigen-1TIA1 protein, humanadmixturegene based rare variant analysisgenome-wide associationheritability enrichmentlow coverage sequencing

Identifiers

PMID28436151
PMCPMC5435561

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.