ArticleCurrent topics in behavioral neurosciences
Neurobiological Programming of Early Life Stress: Functional Development of Amygdala-Prefrontal Circuitry and Vulnerability for Stress-Related Psychopathology.
Article in Current topics in behavioral neurosciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.
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Who cites it
95 citing papers in PubMed, 2 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- How childhood adversity affects components of decision making.Neuroscience and biobehavioral reviews · 2025Pooled it
- Endocannabinoids and Stress-Related Neurospsychiatric Disorders: A Systematic Review and Meta-Analysis of Basal Concentrations and Response to Acute Psychosocial Stress.Cannabis and cannabinoid research · 2024Pooled it
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Differential adolescent neurodevelopment of emotion processing across internalizing psychopathology and childhood adversity.Developmental cognitive neuroscience · 2026Article
- Early Life Stress Affects Human Decision Making by Increasing Expectations of Volatility.Developmental science · 2026Article
- Neurodevelopmental impacts of unique postnatal adversity subgroups in children with prenatal alcohol exposure.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2026Article
- Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles.Neurobiology of stress · 2026Article
- Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo.Molecular psychiatry · 2026Article
- Sad emotion processing-related theta oscillation patterns link suicide attempt to childhood trauma in depression: evidence from MEG.Translational psychiatry · 2026Article
- Early life chronic stress-disrupted activity of the dorsal raphe nucleus selectively drives behavioral impairments.Communications biology · 2026Article
- Attachment Theory: Novel Clinical and Molecular Insights.Biomolecules · 2026Review
- The double-edged sword effect of adverse childhood experiences forging adult stress into depression and anxiety.Scientific reports · 2025Article
- Article
- Neonatal estradiol and early adversity interact to modify basolateral amygdala morphology and adult behavior in female rats.Journal of neuroendocrinology · 2025Article
- Effects of early life stress on network and behavioral states.Psychoneuroendocrinology · 2025Article
- Associations of prenatal stress with 5-year-old children's executive function in a low socioeconomic status population.Development and psychopathology · 2025Article
- Validation of an electronic self-administered version of the Dimensional Inventory of Stress and Trauma Across the Lifespan in a large sample of young adults.Psychological trauma : theory, research, practice and policy · 2025Article
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- The long-term correlates of developmental stress on whole-brain functional connectivity during emotion regulation.Translational psychiatry · 2025Article
- Alterations in cerebral resting state functional connectivity associated with social anxiety disorder and early life adversities.Translational psychiatry · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Early adverse experiences are associated with heighted vulnerability for stress-related psychopathology across the lifespan. While extensive work has investigated the effects of early adversity on neurobiology in adulthood, developmental approaches can provide further insight on the neurobiological mechanisms that link early experiences and long-term mental health outcomes. In the current review, we discuss the role of emotion regulation circuitry implicated in stress-related psychopathology from a developmental and transdiagnostic perspective. We highlight converging evidence suggesting that multiple forms of early adverse experiences impact the functional development of amygdala-prefrontal circuitry. Next, we discuss how adversity-induced alterations in amygdala-prefrontal development are associated with symptoms of emotion dysregulation and psychopathology. Additionally, we discuss potential mechanisms through which protective factors may buffer the effects of early adversity on amygdala-prefrontal development to confer more adaptive long-term outcomes. Finally, we consider limitations of the existing literature and make suggestions for future longitudinal and translational research that can better elucidate the mechanisms linking early adversity, neurobiology, and emotional phenotypes. Together, these findings may provide further insight into the neuro-developmental mechanisms underlying the emergence of adversity-related emotional disorders and facilitate the development of targeted interventions that can ameliorate risk for psychopathology in youth exposed to early life stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.