Evidence map›Paper›PMID 28443609›Full record

ArticleMucosal immunology2018

The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry.

Z Zhou, L Xu, A Sennepin, C Federici, Y Ganor, D Tudor, D Damotte, N Barry Delongchamps, M Zerbib, M Bomsel

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Z ZhouMucosal Entry of HIV-1 and Mucosal Immunity, Infection, Immunity and Inflammation Department, Cochin Institute, Université Paris Descartes, Paris, France.
L XuMucosal Entry of HIV-1 and Mucosal Immunity, Infection, Immunity and Inflammation Department, Cochin Institute, Université Paris Descartes, Paris, France.
A SennepinMucosal Entry of HIV-1 and Mucosal Immunity, Infection, Immunity and Inflammation Department, Cochin Institute, Université Paris Descartes, Paris, France.
C FedericiINSERM, U1016, Paris, France.
Y GanorMucosal Entry of HIV-1 and Mucosal Immunity, Infection, Immunity and Inflammation Department, Cochin Institute, Université Paris Descartes, Paris, France.
D TudorMucosal Entry of HIV-1 and Mucosal Immunity, Infection, Immunity and Inflammation Department, Cochin Institute, Université Paris Descartes, Paris, France.
D DamotteAnatomy and Pathological Cytology Service, GH Cochin-St Vincent de Paul, Paris, France.
N Barry DelongchampsUrology Service, GH Cochin-St Vincent de Paul, Paris, France.
M ZerbibUrology Service, GH Cochin-St Vincent de Paul, Paris, France.
M BomselMucosal Entry of HIV-1 and Mucosal Immunity, Infection, Immunity and Inflammation Department, Cochin Institute, Université Paris Descartes, Paris, France.
Centre National de la Recherche Scientifique · FRHôpital Saint-Vincent-de-Paul · FRInserm · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complexity of signal transduction resulting from the contact of human immunodeficiency virus type 1 (HIV-1)-infected cells and mucosal cells has hampered our comprehension of HIV-1 mucosal entry. Such process is driven efficiently only by viral synapse contacts, whereas cell-free HIV-1 remains poorly infectious. Using CD4

Indexed as

Adaptive ImmunityCells, CulturedCytokinesForeskinHIV-1HIV InfectionsHumansImmunity, InnateKeratinocytesMaleMicroRNAsNF-kappa BRNA, Small InterferingSignal TransductionTh2 CellsThymic Stromal LymphopoietinCytokinesMicroRNAsMIRN375 microRNA, humanNF-kappa BRNA, Small InterferingThymic Stromal LymphopoietinTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID28443609
OpenAlexW2608911327

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.