Evidence map›Paper›PMID 28468816›Full record

ArticleG3 (Bethesda, Md.)2017

Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in

Katherine A McCulloch, Yingchuan B Qi, Seika Takayanagi-Kiya, Yishi Jin, Salvatore J Cherra

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Life science alliance · 2024
    Article
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  11. Sphingosine Kinase Regulates Neuropeptide Secretion During the Oxidative Stress-Response Through Intertissue Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katherine A McCullochSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093.
Yingchuan B QiSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093.
Seika Takayanagi-KiyaSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093.
Yishi JinSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 yijin@ucsd.edu scherra@ucsd.edu.ORCID 0000-0002-9371-9860
Salvatore J CherraSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 yijin@ucsd.edu scherra@ucsd.edu.
University of California, San Diego · USHoward Hughes Medical Institute · US

Funding

TRAINING IN THE NEUROPLASTICITY OF AGINGT32AG000216 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOO, EDWARD H. · 1992 to 2017
$8.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
GABAERGIC NEURON DIFFERENTIATION IN C ELEGANSR01NS035546 · NINDS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JIN, YISHI · 1996 to 2016
$5.3M
NEUROBIOLOGY TRAINING PROGRAMT32NS007220 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIN, YISHI · 1985 to 2023
$4.5M
GABAergic Neuron Differentiation in C.elegansR37NS035546 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIN, YISHI · 2017 to 2021
$2.4M
Understanding the molecular mechanisms that maintain excitation-inhibition balance in neural circuitsK99NS097638 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHERRA, SALVATORE JAMES · 2016 to 2017
$182k
Identification of genetic pathways that regulate neuronal circuits in C. elegansF32NS081945 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHERRA, SALVATORE JAMES · 2012 to 2015
$153k
Howard Hughes Medical InstituteNIA NIH HHS T32 AG000216NIH HHS P40 OD010440NINDS NIH HHS F32 NS081945NINDS NIH HHS K99 NS097638NINDS NIH HHS R01 NS035546NINDS NIH HHS R37 NS035546NINDS NIH HHS T32 NS007220
6 · The paper itself

Abstract

Acetylcholine (ACh) receptors (AChR) regulate neural circuit activity in multiple contexts. In humans, mutations in ionotropic acetylcholine receptor (iAChR) genes can cause neurological disorders, including myasthenia gravis and epilepsy. In

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsMutationReceptors, CholinergicAnimalsCholinergic NeuronsLocomotionSynaptic TransmissionCaenorhabditis elegans ProteinsReceptors, Cholinergicacetylcholine receptoracetylcholine transporterepilepsylipidlocomotionmajor facilitator superfamily domain (MFSD) proteinsseizuresphingosine kinase/sphk-1unc-17

Identifiers

PMID28468816
PMCPMC5499116
OpenAlexW2610939863

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.