Evidence map›Paper›PMID 28469971›Full record

ArticleAmerican journal of cancer research2017

Alpinumisoflavone suppresses tumour growth and metastasis of clear-cell renal cell carcinoma.

Tingting Wang, Yuhua Jiang, Lei Chu, Tianhui Wu, Jie You

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tingting WangShanghai Ninth People's Hospital, Shanghai JiaoTong University School of MedicineShanghai 200011, China.
Yuhua JiangTumor Hospital of QingdaoShandong 266042, China.
Lei ChuTumor Hospital of QingdaoShandong 266042, China.
Tianhui WuQingdao 5th People's HospitalQingdao 266002, Shandong, China.
Jie YouShanghai Ninth People's Hospital, Shanghai JiaoTong University School of MedicineShanghai 200011, China.
Shandong Tumor Hospital · CNShanghai Ninth People's Hospital · CNQingdao Eighth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. The present study is aimed to investigate the role of alpinumisoflavone (AIF), a naturally occurring flavonoid compound, in ccRCC and the underlying mechanism. In this study, miR-101 has been identified as a novel therapeutic target, which exerts anti-tumor effect on ccRCC by directly targeting RLIP76. Moreover, our results showed that AIF was able to increase the expression of miR-101 by suppressing Akt signalling. Our findings in this study provided experimental evidence that AIF has the potential to be used as an agent in the treatment of ccRCC.

Indexed as

Alpinumisoflavoneclear cell renal cell carcinomamiR-101RLIP76

Identifiers

PMID28469971
PMCPMC5411806
OpenAlexW2994868601

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.