GLP-1 receptor agonists × inflammation & biomarkers

SynthesisJournal of diabetes and its complications2017

Treatment with GLP1 receptor agonists reduce serum CRP concentrations in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.

Mohsen Mazidi et al.PubMed ↗Publisher ↗

  • GLP-1 RAslooks good hereLower serum CRP concentrations.Randomised, small.

What the trial testedrandomised · 2017

Randomised vs control (placebo or standard care, as implied by RCT context)

Probably lowered serum CRP concentrations

−2.14−3.51 to −0.78

GLP-1 RAs vs control (placebo or standard care, as implied by RCT context)

As reported

difference −2.14, 95% CI −3.51 to −0.78

Who was studied, and how

people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

GLP-1 RAs
control (placebo or standard care, as implied by RCT context)

Probably lowered serum CRP concentrations−2.14

randomised

the abstract, start to end

following treatment with GLP-1 RAs (WMD -2.14 (mg/dL), 95% CI -3.51, -0.78,

← favours treatmentfavours comparator →
could be chance
Serum CRP concentrationsGLP-1 RAs vs control (placebo or standard care, as implied by RCT context)
−2.14−3.51 to −0.78
GLP-1 receptor agonistsInflammation & biomarkers

GLP-1 receptor agonists × inflammation & biomarkershelps?mixed

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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43 papers cite it

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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 28479155